DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBR1 and H15

DIOPT Version :9

Sequence 1:	NP_006584.1	Gene:	TBR1 / 10716	HGNCID:	11590	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_608926.2	Gene:	H15 / 33769	FlyBaseID:	FBgn0016660	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	189/651 - (29%)
Similarity:	258/651 - (39%)	Gaps:	153/651 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     4 EHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKIT---------RGM 59
            :..:|.:...:....|.||.:.|.....   |.||:.:..::......:...|         ||
  Fly    30 QQIVSAAAAAAANIANGSSHHHHHQNHH---HHHPLNNHHNHNHNQHNISFATDFSIAAIMARG- 90

Human    60 TNQSDTDNFPDSKD------SPGDVQRSKLSPVLDGV---------SEL--------RHSFDGSA 101
                  .|.|.|::      ||..|:|.......|.|         ||:        ..:...:|
  Fly    91 ------GNAPSSREPSERSLSPASVERYSGQDADDDVDVDVVDCSDSEMPSATAAAAAAATTAAA 149

Human   102 ADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIGSPSR-YMAHHPVITNGAYNSLLSN-- 163
            |...|.:|....|:...|.........|....|...:.|...| :..||...||.:.||..||
  Fly   150 AAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTNNSSNSGNSNTN 214

Human   164 ---SSPQG----------YPTAGYPYPQQYGHSYQGAPFYQFSSTQP-----------GLVPGKA 204
               ||.:|          .|:...|.|.|.....:.....:..:.||           .|.|  .
  Fly   215 SKSSSQRGRSAAAVGAAATPSPPPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTP--V 277

Human   205 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWR 265
            |.:|..:.||.|||...|||||||.||||||.:..:.||    :.|...|.:.:||:..|...:|
  Fly   278 QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYR 342

Human   266 --FQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQ 328
              :....|:..||||. ...:|:|.|||.|.:.....:|.:||.|:|||||:  .:.:|| |||.
  Fly   343 YAYHRSSWLVAGKADP-PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE--MDKSGQ-VVLN 403

Human   329 SLHKYQPRLHVVEVNEDGTEDTSQPGRVQ-----TFTFPETQFIAVTAYQNTDITQLKIDHNPFA 388
            |:|:||||:|:|.::. |......|..:|     ||.||||.|.|||||||..||:||||.||||
  Fly   404 SMHRYQPRIHLVRLSH-GQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFA 467

Human   389 KGFRDNYDTIYTGCDMDR-----------LTPSP----NDSPRSQIVPGARYAMAGSFLQDQFVS 438
            |||||:...    .|.||           :..:|    .|...||:.|....|.:.:.|:
  Fly   468 KGFRDSSRL----SDFDRDPMDAFFFDQHMRTAPLRFFPDPLMSQLTPQEADAASMALLE----- 523

Human   439 NYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSP-----------QRWFVTPANNR 492
               |||.|... .|..|.|:..:||   |.....|..|..|:|           |:|....|.
  Fly   524 ---KARQHLQM-FGRSPYTEMLLPH---LYQRSAAPPPPPPAPHLSAFQLGMWQQQWPQLTAG-- 579

Human   493 LDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGTK 557
              |.|||         |....|:.||||....|        .|....|.|:   ..:|...||:.
  Fly   580 --FLASA---------NQQAALALAAAGANRTP--------PPSMAVAPPA---PATPTSSCGSA 622

Human   558 S 558
            |
  Fly   623 S 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		3/18 (17%)
		T-box_TBR1	203..393	CDD:410330	91/200 (46%)
		T-box_assoc	418..680	CDD:406561	39/152 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..658
H15	NP_608926.2	TBOX	276..475	CDD:238106	94/205 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740