DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBR1 and org-1

DIOPT Version :9

Sequence 1:	NP_006584.1	Gene:	TBR1 / 10716	HGNCID:	11590	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	137/443 - (30%)
Similarity:	195/443 - (44%)	Gaps:	108/443 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     3 LEHCLSPS-------IMLSKKFLNVS--------SSY---PH-SGGSELVLHDHPIISTTDNLER 48
            :.|.:.|:       ...|.:||:.|        :.|   |: :||...:......|.|... :|
  Fly     1 MTHLMGPTECAGAMMTTTSMQFLDTSLTDYNCYGNDYWTSPYMTGGLSPMKQIEACIQTAGK-DR 64

Human    49 SS--PLKKI----------TRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSA 101
            ||  ||::|          :.|.|..:::::...|..:|                        |.
  Fly    65 SSYKPLEQIDAKLADIETHSTGSTGTANSNSSTSSISNP------------------------SC 105

Human   102 ADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIG----------------SPSRYMAHHP 150
            .|:    .||...|:.:.|:   .|.|.|..|..|.:.|                :..::...|.
  Fly   106 PDQ----SSSSSSSSVSLPT---DYAGVHSEASMAPTAGGTAVTTTSAGGVSASTASKKFKGQHK 163

Human   151 VITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWL 215
            ...|.|.|..:..:|                |:....   :.....|.|  .:|.|.|..:.||.
  Fly   164 KDNNSAENGTVKPNS----------------HNISKG---ESEPVHPSL--AQAIVVLETKALWD 207

Human   216 KFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWR--FQGGKWVPCGKAD 278
            :||...|||||||.||||||.....|.||||.|.|...:|.:..|...:|  |....||..||||
  Fly   208 QFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKAD 272

Human   279 TNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEV- 342
            . :...|:::|||||..|::||:|.:||.|||||||:  .:.||. ::|.|:|:||||.|:|.:
  Fly   273 P-ISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQ--LDENGH-IILNSMHRYQPRFHLVYLP 333

Human   343 -NEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDN 394
             .....::.......:||.||||.|.|||||||..:|||||..|||||||||:
  Fly   334 PKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDD 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		4/18 (22%)
		T-box_TBR1	203..393	CDD:410330	93/193 (48%)
		T-box_assoc	418..680	CDD:406561
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..658
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	95/196 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910