DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBR1 and bi

DIOPT Version :9

Sequence 1:	NP_006584.1	Gene:	TBR1 / 10716	HGNCID:	11590	Length:	682	Species:	Homo sapiens
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	204/675 - (30%)
Similarity:	272/675 - (40%)	Gaps:	174/675 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    19 NVSSSYPHSGGSEL---VLHDHPIISTTDNLERSSPLKKITRGM--TNQSDTDNFPDSKDSPGDV 78
            |:.:..|..||::|   ..|.....:||.|...||.........  .|.:.|:|..::.::....
  Fly    80 NLVAVSPTGGGAQLSPQSNHSSSNTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTSQK 144

Human    79 QRSKLS-------------PVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQH 130
            |...||             |.:.|:..:....:.|::     |.|:...|||..|| ..|....|
  Fly   145 QGHHLSTTEEPPSPAGTPPPTIVGLPPIPPPNNNSSS-----SSSNNSASAAAHPS-HHPTAAHH 203

Human   131 GP-----AHPAFSIGSPSRYMAHH----------------PVITNGAYNSLLSNSSPQG-----Y 169
            .|     |.||.:.|.|.....||                |.....|..:|.  .||.|     |
  Fly   204 SPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALA--GSPAGPHPGLY 266

Human   170 PTAG----------YPYPQQYGHSYQGAPFYQFSST-----QPGLVPGKA------------QVY 207
            |..|          :|:....|.:|..|.....:|.     .|.:.|.:|            :|.
  Fly   267 PGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVT 331

Human   208 LCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWV 272
            |..:.||.|||:..|||:|||.||:|||.:.|.:||||..|.|.:.:|::.||...::|...:|:
  Fly   332 LEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWM 396

Human   273 PCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRL 337
            ..||||..:. .|:|:|||||.||..||::.:||.|||||||....:......:|.|:||||||.
  Fly   397 VAGKADPEMP-KRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRF 460

Human   338 HVVEVNEDGTEDTSQP-GRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRD-------- 393
            |:|..|    :....| ...:|:.|.||:|||||||||..|||||||:|||||||||
  Fly   461 HLVRAN----DILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREK 521

Human   394 ------NYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAG 452
                  |     .|.|.|:|.|:...|.|                          |..|.|....
  Fly   522 KQALMSN-----RGSDSDKLNPTHVSSSR--------------------------APLHLGHAGR 555

Human   453 PGPGTDRSVPHTN---GLLSPQQAEDP------GAP-SPQRWFVTPANNRL-DFAASAYDTA--- 503
            |        ||.:   .||..||.:|.      |.| ||    :.|.::.| ...|..:..|
  Fly   556 P--------PHLHPHAALLDNQQDDDDKLLDVVGPPQSP----LLPLSHSLQQMHAHQHSAALAA 608

Human   504 --TDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYC-----GTKSGSV 561
              ...||..|....:|||.  |....|.....|.|...||....|:.|.   |     |:..|:.
  Fly   609 WFNHLAGAGAGASEHAAAA--AANASAEDALRRRLQADADVERDGSDSS---CSESVGGSTGGAF 668

Human   562 LPCWPNS------AAAAARMAGANP 580
            .|....|      |||||..||.||
  Fly   669 RPTSTGSPKEAVGAAAAAAAAGLNP 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		8/18 (44%)
		T-box_TBR1	203..393	CDD:410330	94/202 (47%)
		T-box_assoc	418..680	CDD:406561	47/190 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		13/45 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..658
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	12/57 (21%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	93/187 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810