DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrtm2 and Fili

DIOPT Version :9

Sequence 1:	NP_821072.1	Gene:	Lrrtm2 / 107065	MGIID:	2389174	Length:	515	Species:	Mus musculus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	136/565 - (24%)
Similarity:	209/565 - (36%)	Gaps:	147/565 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 WPLGA-PMLAAIYAMSVVLKMLPALGMACPPKCRC------EKLLFYCDSQGFHSVPNATDKGSL 64
            |..|| |:|..:....|:|.  |.....||.||:|      .:.|  |.......||...:..:.
  Fly    16 WLCGAIPVLLLLLLTLVILP--PETTAFCPSKCQCLGGEANSRAL--CVDAALEDVPIQLNPETK 76

Mouse    65 GLSLRHNHITALE-----------------------RDQFASFSQLTWLHLDHNQISTVKEDAFQ 106
            .::|..|.|..||                       ...|...|:|..|:|..|.:|::.:.||:
  Fly    77 YINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFK 141

Mouse   107 GLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRT 171
            ||..|..|.||.|:|..:..|..:.|.:|..|||:.|.:.||....|.|:..|:.|..|:|.|..
  Fly   142 GLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLD 206

Mouse   172 IPVRLFWDCRSLEFLDLSTNRLRSLARN-------------------------GFAGLIKLRELH 211
            :|....|...:|:.||:|.| |....||                         .|.|||.|:.|.
  Fly   207 VPASNLWHLHALKSLDMSLN-LVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLD 270

Mouse   212 LEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTC---------------GMDWTW--------- 252
            |..|.||.:......:||:|..|.|..|:.|.|..               .:|:..
  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335

Mouse   253 -STLEKLDLTGN-EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWEC 315
             :.|:.|.|..| ::..|.:.:|:..||:..:.|.:|.|.:|.|... .:..|..:.|..|..:|
  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQC 399

Mouse   316 SPRVCALASWL-----GSFQG---RWEH------SILCHSPDHTQGEDILDAVHGFQLCWNLST- 365
            :   |:|. ||     |:|:|   ..||      :.|....|..:..|...||        .||
  Fly   400 N---CSLL-WLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAV--------ASTD 452

Mouse   366 --------------TVTAMATTYRDPTTEYTKISSSSYHVG---------------DKEIPTTAG 401
                          .|.|:.||  :|:......|||:.:.|               || :.|...
  Fly   453 DGVAALAAYIAEQHIVNALHTT--EPSAYELATSSSNRNSGILRMDRQQIGCDIWRDK-VRTRRK 514

Mouse   402 IAVTTEEHFPEPDNAI-FTQRVITGTMALLFSFFFIIFIVFISRK 445
            :...:|.....|.:.: ....|||..:..:.....:.::.|:.|:
  Fly   515 LLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRR 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm2	NP_821072.1	LRR 1	63..83		6/42 (14%)
		LRR	<65..312	CDD:227223	82/320 (26%)
		leucine-rich repeat	66..86	CDD:275380	6/42 (14%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR 6	182..203		9/45 (20%)
		leucine-rich repeat	183..206	CDD:275380	11/47 (23%)
		LRR 7	206..227		6/20 (30%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		LRR 8	230..251		7/35 (20%)
		leucine-rich repeat	231..254	CDD:275380	7/47 (15%)
		LRR 9	254..275		6/21 (29%)
		leucine-rich repeat	255..278	CDD:275380	6/23 (26%)
		LRR 10	278..299		6/20 (30%)
		leucine-rich repeat	279..300	CDD:275380	5/20 (25%)
		PCC	284..>351	CDD:188093	21/80 (26%)
		Involved in DLG4-binding. /evidence=ECO:0000250	512..515
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	23/59 (39%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	49/193 (25%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	11/47 (23%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	1/23 (4%)
		LRR_8	337..397	CDD:404697	16/60 (27%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910