DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCY1 and Ac78C

DIOPT Version :9

Sequence 1:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	1378	Identity:	399/1378 - (28%)
Similarity:	603/1378 - (43%)	Gaps:	404/1378 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    11 GGGGAGEPGGAERAAGTSRRRGLRACD--EEFACP---------ELEALFRGYTLRLEQAATLKA 64
            |...|..||.::|..........::.:  :...||         .||..:..||.|..|    |:
  Fly   267 GNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQ----KS 327

Human    65 LAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129
            |.::::                          |..||.:.|..|..:|..::..::.....::..
  Fly   328 LIIVNV--------------------------VDFVLKIVLAFVWIMRRSELGPIESDDGTSMAT 366

Human   130 SLTFALLC--------------------------CPFALGGPARGSAGAAGGPATAEQGVWQLLL 168
            ::|:::.|                          |.:.|.. .:|..|...|.|..|..||.:|.
  Fly   367 AITWSVCCGIANMAICFLGYWRCFANNYLHWAAVCTWVLFN-IQGFVGQGVGFADREYLVWYILF 430

Human   169 VTFVSYALLPVRSLLAIGFGLVVAASHLLV---------TATLVPAKRPRLWRTLGANALLFVGV 224
            |.||.||:||:.....:..|.:.|:.||.|         .||:.|   ..:...:.||.:|:..:
  Fly   431 VIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINP---ECVLFQIFANFILYTAI 492

Human   225 NMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK---- 285
            |:.|::.:.||:|.||.||::....:|.:...|.|.::.::||.|:||..|..:::.:..|
  Fly   493 NVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDP 557

Human   286 PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKIL 350
            ..|..|:|:|:...||||||||||.|||.|||:.:||:|||:||:||.:||.:|.:|||.|:|:|
  Fly   558 TVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLL 622

Human   351 GDCYYCVSGL------TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVL 409
            ||||||||..      |:|  |||.|.||.||.||..|..|...|.||||||:|:|:|.|:||||
  Fly   623 GDCYYCVSQFESDNWKTRP--DHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVL 685

Human   410 GLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETF 474
            |.:||.:|||||||.:||.||:.|:||:|||::.||.|||..||||||.|..|::.||..|::|:
  Fly   686 GNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNVKTY 750

Human   475 FI--------------------------------------------------------------- 476
            .|
  Fly   751 LIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASID 815

Human   477 -----------VPS----------HRRKI----FPGLILSDIKPAKRMK---------------- 500
                       ||:          .::.|    .|.::......::|::
  Fly   816 GRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGG 880

Human   501 -----FKTV--------CYLLVQL------MHCRKMFKA------------------EIPFSNVM 528
                 ..||        ..|.|||      ...:.:.:|                  ||||.|:.
  Fly   881 TGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLN 945

Human   529 TCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQT-ELEMADLNFFTLKY 592
            :.||...|........|..:|.|.:      .....::.:|.:.::.... |:....||.:|||:
  Fly   946 SPEDGLNRADSILVDTKEDHRVSVA------VLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKF 1004

Human   593 KHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLL-------LLVFCICFLVA 650
            |...:|||:.||:::.|.|.::...::.....|..::|.|:...:::       :|.||
  Fly  1005 KDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFC------ 1063

Human   651 CVLYLHITRVQCFPG---CLTI---------QIRTVLCIFIVVLIYSVAQGCVVGCL-------- 695
            |||.:    .:.|||   ||..         |.||   :||..:|.|:.....:|.:
  Fly  1064 CVLVM----AEEFPGLPRCLKTNSAKLVHQRQRRT---LFICGVIVSMCMLSAIGLVLCPSSTYI 1121

Human   696 --------------PWA---------------------------------------WSSKPNSSL 707
                          |::                                       .||.|:...
  Fly  1122 GTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEF 1186

Human   708 V----------------------VLSSGGQRTALPTL----------------PCESTHHAL--- 731
            |                      .|::.|...:|..|                .|....:.:
  Fly  1187 VRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTW 1251

Human   732 LCCLVG-TLPLAIFFRVSSLPKMILLSGLTT----------SYILVLELSGYTRTGGGAVSGRSY 785
            :.|||. ...|.:::.|.:|..:.:::..||          |:.|| |||   |.|    .....
  Fly  1252 VLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLV-ELS---RLG----MPLGV 1308

Human   786 EPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFL 850
            :.::.::.|...:..|||.|::..|||::|..|||.|..:|:..:..|..::.|:||.|||.::|
  Fly  1309 QMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILPDHVATYYL 1373

Human   851 MSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKD 915
             |:....:||.:.::..||||||||||.|||.| |.:| |..|:|:|||||.|||||:|:..:..
  Fly  1374 -SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDELLEEPRFAS 1435

Human   916 IEKIKTIGSTYMAAVGL----APTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLR 976
            :|||||:|:|||||.||    ....|..::.|:..    |.:||..|...|:|||..::|:|.||
  Fly  1436 VEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCD----LVEFAFAMKQKLEEINGDAFNNFQLR 1496

Human   977 VGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKV 1041
            |||..||:|:||||||:|.||||||||||||||||||...|:||.|....||....|..|.||::
  Fly  1497 VGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYTCVKRGEI 1561

Human  1042 SVKGKGEMLTYFL 1054
            :|||||.|.|:::
  Fly  1562 AVKGKGMMTTFYV 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/16 (31%)
		AC_N	<161..292	CDD:292831	41/143 (29%)
		CYCc	258..453	CDD:214485	108/204 (53%)
		Guanylate_cyc	294..476	CDD:278633	109/187 (58%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		7/61 (11%)
		CYCc	826..1037	CDD:214485	107/214 (50%)
		Guanylate_cyc	859..1056	CDD:278633	107/200 (54%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		9/22 (41%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	64/296 (22%)
		CYCc	526..729	CDD:214485	108/204 (53%)
		Guanylate_cyc	566..753	CDD:278633	109/188 (58%)
		DUF1053	929..1020	CDD:283888	24/96 (25%)
		CYCc	1353..1554	CDD:214485	105/207 (51%)
		Guanylate_cyc	1381..1576	CDD:278633	107/200 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710