DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CORIN and fz2

DIOPT Version :9

Sequence 1:	NP_006578.2	Gene:	CORIN / 10699	HGNCID:	19012	Length:	1042	Species:	Homo sapiens
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	93/399 - (23%)
Similarity:	140/399 - (35%)	Gaps:	125/399 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   444 DPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMF 508
            |||      .:||.||:.:|..:.||.||:||...|.||.||.:  |...|..||:..|...|.|
  Fly    59 DPN------LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGL--EVHQFWPLVEIKCSPDLKF 115

Human   509 FSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMP 573
            |.|::..|.|..:..:.:|.||::||.::..|..::.....:|||...|...|.....:..|:..
  Fly   116 FLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQ 180

Human   574 DEYVE--------------ECSPSHFKCRSG------------QCVLASRRCDGQ--ADCDDDSD 610
            ..|.|              ..|.|..|.:.|            ....:::.|.|:  .:|.:...
  Fly   181 PSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQG 245

Human   611 EE------NCGCK-------ERDLWECPSNKQCLKH--------TV-ICDGFPDC--PDYMDEKN 651
            |:      :|.|:       :..|.:..|....:.|        || ...|.|:|  |
  Fly   246 EKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIP------- 303

Human   652 CS--FCQDDELECANHACVSRDLWC---DGEADCS----------DSS----DEWDCVTLS---- 693
            |.  |..:||.:.|.       ||.   .|...||          |:.    .|...|.||
  Fly   304 CKGPFFSNDEKDFAG-------LWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYF 361

Human   694 ---INVNSSSF----------LMVHRAATEHHVC-------------ADGWQEILSQLACKQMGL 732
               :...|.:|          |::..::|..|.|             :..|..|||.......||
  Fly   362 MVAVGYLSRNFLQNEEIACDGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGL 426

Human   733 --GEPSVTK 739
              |..::||
  Fly   427 KWGNEAITK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554
		LDLa	269..304	CDD:238060
		LDLa	306..340	CDD:238060
		Ldl_recept_a	347..377	CDD:278486
		LDLa	387..414	CDD:238060
		CRD_corin_2	454..575	CDD:143579	39/120 (33%)
		LDLa	580..614	CDD:238060	8/53 (15%)
		LDLa	655..689	CDD:238060	10/50 (20%)
		SR	690..786	CDD:214555	18/82 (22%)
		Tryp_SPc	801..1030	CDD:214473
		Tryp_SPc	802..1033	CDD:238113
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	39/120 (33%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	29/135 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810