DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CORIN and corin

DIOPT Version :9

Sequence 1:	NP_006578.2	Gene:	CORIN / 10699	HGNCID:	19012	Length:	1042	Species:	Homo sapiens
Sequence 2:	XP_009295418.2	Gene:	corin / 100320926	ZFINID:	ZDB-GENE-060224-3	Length:	1036	Species:	Danio rerio

Alignment Length:	1055	Identity:	632/1055 - (59%)
Similarity:	764/1055 - (72%)	Gaps:	64/1055 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    30 MGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVG-----------------TLQKVYF 77
            ||...:........||.||.:|:||:|.|:.:.|:||:..|                 ||....|
Zfish     2 MGEAFTHTQRCGKHLRLLLFILLPCVCVLICVCVLLLTLTGLFGNNGLLDAGAFVSIATLPPPAF 66

Human    78 K---------SNGSEPLVTDGEIQGSDVILTNTIY--NQSTVVSTAHPDQHVPAWTTDASL---- 127
            .         .||:..:.||..:|..     :|::  ...|..|.:.....|..||:.:::
Zfish    67 NDSDSRLMTADNGTVAVPTDAPLQWD-----STLWMPRADTSPSASPTAVSVDWWTSTSTVTSLN 126

Human   128 --PGDQSHRNTSACMNITHSQCQMLPYHATLTPL-LSVVRNMEMEKFLKFFTYLHRLSCYQHIML 189
              ||        .|.:||.|||.||||:.:...: .|||::.|::.|||||:||.|||||:||||
Zfish   127 AEPG--------ICSDITESQCNMLPYNQSGVMVGRSVVKSSELQMFLKFFSYLSRLSCYRHIML 183

Human   190 FGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQ--TESSNV 252
            |||::|.|:||...|....:|||:||||||:||||.||.|.|.|||:|||||||.|.  |...|.
Zfish   184 FGCSIALPQCISHRDGRTLVLPCQSFCEAAREGCEPVLQMFNASWPEFLRCSQFSNNSGTAVENT 248

Human   253 SRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGK 317
            : :|::|:...||..:||..::||||:|||:|.||.||||||||||||||.|.|::....|.||:
Zfish   249 A-LCYTPKHARGKLSVCGGNDHFLCATGICVPLKLVCNGYNDCDDWSDEADCTCADTQHLCGTGR 312

Human   318 CLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQ 382
            |:|..|:||||||||||||||||.|:...||.|||||||..||:|||||||:|||||:||||.||
Zfish   313 CINSDLLCDGYDDCGDLSDEQNCVCDELEEHHCGDGRCIPREWLCDGDHDCLDKSDELNCSCKSQ 377

Human   383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV--IQTSCQEGDQRCLYNPCLDSCGGSSLCDP 445
            |||||:|.|||||.|:|||::|||||||||||:.  ||..|..|...|....|   |.|::.||.
Zfish   378 GLVECKNKQCIPSAFRCDGEDDCKDGSDEENCTQQHIQGLCPSGQSGCSSTSC---CPGNTSCDL 439

Human   446 NNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFS 510
            ..:.||||.||||:||:|||||||:|.:|||.||::|||.|:||||||||||||||||||||||:
Zfish   440 RTAGNNCSDCEPISLEICMNLPYNTTRFPNYLGHQSQKETSVSWESSLFPALVQTNCYKYLMFFA 504

Human   511 CTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDE 575
            ||:|||.||..|.:.:||||:||.:||:|||||||||||||||||||:|||||...|.:||:||.
Zfish   505 CTVLVPMCDPVTQQRVPPCRSLCRNSKDRCESVLGIVGLQWPEDTDCAQFPEEGQANSSCLLPDP 569

Human   576 YVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGF 640
            .|.||||||||||||:|||:|:||||..|||||||||.|||.||.|||||.:|.|:.|::|||||
Zfish   570 DVNECSPSHFKCRSGRCVLSSKRCDGHTDCDDDSDEEMCGCLERGLWECPGDKSCIPHSMICDGF 634

Human   641 PDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVH 705
            |||..:.||.|||.|...||||.||.||.|.|||||...||||||||:||:||    ....|:|:
Zfish   635 PDCSQHEDENNCSACSSHELECNNHECVHRALWCDGRRHCSDSSDEWNCVSLS----DEGSLLVY 695

Human   706 RAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQE---KEPRWLTLHSNWESLNGTTLHE 767
            :|..|:|||||||....|.:.|.|||||.|..|..:.:..   :..|||.:..:|...|...|..
Zfish   696 KAGLEYHVCADGWSPNHSSVTCTQMGLGSPLSTDAMLDVSPVVRRKRWLHVDPDWSPENMLPLQG 760

Human   768 LL-VNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCV 831
            || ..||||:|..||||.||:.:||||||||:.||||||||||||||||||||||:|||||||||
Zfish   761 LLEKRGQSCQSYKKISLQCTRDECGRRPAARLVKRILGGRTSRPGRWPWQCSLQSDPSGHICGCV 825

Human   832 LIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIV 896
            ||..||.|||||||||||:|.|||||||||||||||.:||||.||:||:|.||:|||||||||::
Zfish   826 LIGNKWALTVAHCFEGRESADVWKVVLGINNLDHPSPYMQTRRVKSIIVHSRYNRAVVDYDISVL 890

Human   897 ELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDM 961
            ||..::..|.||||||||...|..:||.||:||||||:||:||||||||||||||:..|||||||
Zfish   891 ELESEVLVTSYVRPVCLPRHGQLPKPDKYCHITGWGHVGNRMPFKLQEGEVRIISVSQCQSYFDM 955

Human   962 KTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYF 1026
            ||||:||:|||||:||:||||||||||||||:..|.|:|:|||||||||||||||||||:||::|
Zfish   956 KTITSRMLCAGYEAGTIDSCMGDSGGPLVCEEDDGHWSLYGLTSWGSVCFSKVLGPGVYANVTHF 1020

Human  1027 VEWIKRQIYIQTFLL 1041
            .|||:||||::||.|
Zfish  1021 TEWIERQIYLRTFNL 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554	70/130 (54%)
		LDLa	269..304	CDD:238060	26/34 (76%)
		LDLa	306..340	CDD:238060	21/33 (64%)
		Ldl_recept_a	347..377	CDD:278486	23/29 (79%)
		LDLa	387..414	CDD:238060	20/26 (77%)
		CRD_corin_2	454..575	CDD:143579	89/120 (74%)
		LDLa	580..614	CDD:238060	28/33 (85%)
		LDLa	655..689	CDD:238060	23/33 (70%)
		SR	690..786	CDD:214555	40/99 (40%)
		Tryp_SPc	801..1030	CDD:214473	179/228 (79%)
		Tryp_SPc	802..1033	CDD:238113	180/230 (78%)
corin	XP_009295418.2	CRD_corin_1	136..258	CDD:143554	68/122 (56%)
		LDLa	268..299	CDD:238060	24/30 (80%)
		LDLa	301..335	CDD:238060	21/33 (64%)
		Ldl_recept_a	342..372	CDD:278486	23/29 (79%)
		LDLa	382..409	CDD:238060	20/26 (77%)
		CRD_corin_2	448..569	CDD:143579	89/120 (74%)
		LDLa	574..608	CDD:238060	28/33 (85%)
		LDLa	<620..646	CDD:238060	13/25 (52%)
		LDLa	649..683	CDD:238060	23/33 (70%)
		SR	689..>728	CDD:214555	19/38 (50%)
		Tryp_SPc	796..1027	CDD:238113	180/230 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340690
Domainoid	1	1.000	404	1.000	Domainoid score	I4517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4804
Inparanoid	1	1.050	1209	1.000	Inparanoid score	I1579
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39432
OrthoDB	1	1.010	-	-		D302217at33208
OrthoFinder	1	1.000	-	-		FOG0007867
OrthoInspector	1	1.000	-	-		oto42843
orthoMCL	1	0.900	-	-		OOG6_107940
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4386
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410