Protein Alignment CORIN and corin

DIOPT Version :10

• Sequence 1: NP_006578.2
• Gene: CORIN / 10699
• HGNCID: 19012
• Length: 1042
• Species: Homo sapiens
• Sequence 2: XP_021325728.2
• Gene: corin / 100320926
• ZFINID: ZDB-GENE-060224-3
• Length: 1036
• Species: Danio rerio
• Alignment Length: 1054
• Identity: 628/1054 - (59%)
• Similarity: 765/1054 - (72%)
• Gaps: 62/1054 - (5%)

Human    30 MGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTL---------------------- 72
            ||...:........||.||.:|:||:|.|:.:.|:||:..|..
Zfish     2 MGEAFTHTQRCGKHLRLLLFILLPCVCVLICVCVLLLTLTGLFGNNGLLDAGAFVSIATFPPPAF 66

Human    73 ----QKVYFKSNGSEPLVTDGEIQGSDVILTNTIY--NQSTVVSTAHPDQHVPAWTTDASL---- 127
                .::....||:..:.||..:|..     :|::  ...|..|.:.....|..||:.:::
Zfish    67 NDSDSRLMTADNGTVAVPTDAPLQWD-----STLWMPRADTSPSASPTAVSVDWWTSTSTVTSLT 126

Human   128 --PGDQSHRNTSACMNITHSQCQMLPYHATLTPL-LSVVRNMEMEKFLKFFTYLHRLSCYQHIML 189
              ||        .|.:||.|||.||||:.:...: .|||::.|::.|||||:||.|||||:||||
Zfish   127 AEPG--------ICSDITESQCNMLPYNQSGVMVGRSVVKSSELQMFLKFFSYLSRLSCYRHIML 183

Human   190 FGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESS-NVS 253
            |||::|.|:||...|....:|||:||||||:||||.||.|.|.|||:|||||||.|.:.:: ..|
Zfish   184 FGCSIALPQCISHRDGRTLVLPCQSFCEAAREGCEPVLQMFNASWPEFLRCSQFSNNSGTAVENS 248

Human   254 RICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKC 318
            .:|::|:...||..:||..::||||:|||:|.||.||||||||||||||.|.|:::...|.||:|
Zfish   249 ALCYTPKHARGKLSVCGGNDHFLCATGICVPLKLVCNGYNDCDDWSDEADCTCADSQHLCGTGRC 313

Human   319 LNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383
            :|..|:||||||||||||||||.|:...||.|||||||..||:|||||||:|||||:||||.|||
Zfish   314 INSDLLCDGYDDCGDLSDEQNCVCDELEEHHCGDGRCIPREWLCDGDHDCLDKSDELNCSCKSQG 378

Human   384 LVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV--IQTSCQEGDQRCLYNPCLDSCGGSSLCDPN 446
            ||||:|.|||||.|:|||::|||||||||||:.  ||..|..|...|....|   |.|::.||..
Zfish   379 LVECKNKQCIPSAFRCDGEDDCKDGSDEENCTQQHIQGLCPSGQSGCSSTSC---CPGNTSCDLR 440

Human   447 NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSC 511
            .:.||||.||||:||:|||||||:|.:|||.||::|||.|:||||||||||||||||||||||:|
Zfish   441 TAGNNCSDCEPISLEICMNLPYNTTRFPNYLGHQSQKETSVSWESSLFPALVQTNCYKYLMFFAC 505

Human   512 TILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEY 576
            |:|||.||..|.:.:||||:||.:||:|||||||||||||||||||:|||||...|.:||:||..
Zfish   506 TVLVPMCDPVTQQRVPPCRSLCRNSKDRCESVLGIVGLQWPEDTDCAQFPEEGQANSSCLLPDPD 570

Human   577 VEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFP 641
            |.||||||||||||:|||:|:||||..|||||||||.|||.||.|||||.:|.|:.|::||||||
Zfish   571 VNECSPSHFKCRSGRCVLSSKRCDGHTDCDDDSDEEMCGCLERGLWECPGDKSCIPHSMICDGFP 635

Human   642 DCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHR 706
            ||..:.||.|||.|...||||.||.||.|.|||||...||||||||:||:||    ....|:|::
Zfish   636 DCSQHEDENNCSACSSHELECNNHECVHRALWCDGRRHCSDSSDEWNCVSLS----DEGSLLVYK 696

Human   707 AATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQE---KEPRWLTLHSNWESLNGTTLHEL 768
            |..|:|||||||....|.:.|.|||||.|..|..:.:..   :..|||.:..:|...|...|..|
Zfish   697 AGLEYHVCADGWSPNHSSVTCTQMGLGSPLSTDAMLDVSPVVRRKRWLHVDPDWSPENMLPLQGL 761

Human   769 L-VNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVL 832
            | ..||||:|..||||.||:.:||||||||:.||||||||||||||||||||||:||||||||||
Zfish   762 LEKRGQSCQSYKKISLQCTRDECGRRPAARLVKRILGGRTSRPGRWPWQCSLQSDPSGHICGCVL 826

Human   833 IAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVE 897
            |..||.|||||||||||:|.|||||||||||||||.:||||.||:||:|.||:|||||||||::|
Zfish   827 IGNKWALTVAHCFEGRESADVWKVVLGINNLDHPSPYMQTRRVKSIIVHSRYNRAVVDYDISVLE 891

Human   898 LSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMK 962
            |..::..|.||||||||...|..:||.||:||||||:||:||||||||||||||:..||||||||
Zfish   892 LESEVLVTSYVRPVCLPRHGQLPKPDKYCHITGWGHVGNRMPFKLQEGEVRIISVSQCQSYFDMK 956

Human   963 TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFV 1027
            |||:||:|||||:||:||||||||||||||:..|.|:|:|||||||||||||||||||:||::|.
Zfish   957 TITSRMLCAGYEAGTIDSCMGDSGGPLVCEEDDGHWSLYGLTSWGSVCFSKVLGPGVYANVTHFT 1021

Human  1028 EWIKRQIYIQTFLL 1041
            |||:||||::||.|
Zfish  1022 EWIERQIYLRTFNL 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554	69/129 (53%)
		LDLa	269..304	CDD:238060	26/34 (76%)
		LDLa	306..340	CDD:238060	21/33 (64%)
		Ldl_recept_a	347..377	CDD:395011	23/29 (79%)
		LDLa	387..414	CDD:238060	20/26 (77%)
		CRD_corin_2	454..575	CDD:143579	89/120 (74%)
		LDLa	580..614	CDD:238060	28/33 (85%)
		LDLa	655..689	CDD:238060	23/33 (70%)
		SR	690..786	CDD:214555	40/99 (40%)
		Tryp_SPc	802..1033	CDD:238113	180/230 (78%)
corin	XP_021325728.2	None