Protein Alignment CCT6B and Hsp60B

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 133/601 - (22%)
• Similarity: 218/601 - (36%)
• Gaps: 151/601 - (25%)

Human     5 KAVNSKAEVAR-----ARAALAVNICAARG---LQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGN 61
            ||:.|....||     .|....|.....||   |.|.:...:||||...::.......|:||||.
  Fly     8 KAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGF 72

Human    62 VLLDEMQI--QHPT--ASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEG 122
            .:...:.:  ||..  |.|:..||...::..|||||:..::...:.|:....|:.|.:|..|..|
  Fly    73 TVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRG 137

Human   123 ----FEAAKIKALEVLEEVKVTKEMKRKILLDV------------------ARTSLQTKVHAELA 165
                .:..|.|..|:.:.|:..:|:::...|..                  .|.::..|....|.
  Fly   138 VMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLK 202

Human   166 DVLTEV--------VVDSVLAVRRPGYPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHP--- 219
            |.|..:        .|.........|..::.....:|....|:...:::::||......|.|
  Fly   203 DELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLII 267

Human   220 ---DMKKRVEDAFIL--------ICNV---SLEYEKTEVNSGFFYKTAE----EKEKLVKAERKF 266
               |:.....:|.:|        :|.|   |..:.:.|:.......|..    :.....|.|...
  Fly   268 IAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAK 332

Human   267 IED--RVQKIIDLKDKVCAQSNK---GFVVINQKGIDPFSLDSLAKHGIVALRRAKRRNMERLSL 326
            :||  :|.:.:..||.......|   |.:.:..:.|.    |.||:..|...:|.:.|  :|||.
  Fly   333 LEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQ----DELAEKQIKPEQRDRLR--QRLSA 391

Human   327 ACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVNPCSVTLLVKGPNKHTLTQVKDAI 391
            ...|:||                                        |.:.|.::..:.:.||.:
  Fly   392 LTKGVAV----------------------------------------LHIGGGSEVEVNEKKDRV 416

Human   392 RDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRA---RLGVQAFADALLIIPKVLAQ 453
            .|.|.|.:.|||:| :|||.|...:    ..:.|...:|..:   :.||....:||.:..:.:||
  Fly   417 VDALNATRAAIEEG-IVPGGGTAFL----RCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQ 476

Human   454 NAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAG---VWDNYC--VKKQLLHSCTVIAT 513
            |||.|....:.||              ||..|     |.|   :.|.||  |:|.::....|:.|
  Fly   477 NAGVDGPMVVAKV--------------LNGSE-----DYGYDAMGDEYCRLVEKGIIDPTKVLRT 522

Human   514 NILLVDEIMRAGMSSL 529
            .|  .|   .||::||
  Fly   523 AI--TD---AAGVASL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	133/601 (22%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	128/587 (22%)