Protein Alignment CCT6B and CCT1

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_524450.2
• Gene: CCT1 / 42649
• FlyBaseID: FBgn0003676
• Length: 557
• Species: Drosophila melanogaster
• Alignment Length: 524
• Identity: 135/524 - (25%)
• Similarity: 259/524 - (49%)
• Gaps: 35/524 - (6%)

Human    23 NICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAKVATAQDDV 87
            |:.||..:.::::::|||.|..||||...||:.:|.||..:|..::::||.|.::.::|..||:.
  Fly    24 NVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVLVELAQLQDEE 88

Human    88 TGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEE--VKVTKEMKRKILLD 150
            .||||||.|::..||||.||..:.:.:||..|..|:..|..:|.:.:.|  .....|:.|..|::
  Fly    89 VGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPVDELGRDSLIN 153

Human   151 VARTSLQTKVHAELADVLTEVVVDSVLAVR------RPGYPIDLFMVEIMEMKHKLGTDTKLIQG 209
            :|:||:.:|:....|:..:.:|||:..:|:      :..|.|.  .:.:::...|...::.||.|
  Fly   154 IAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIK--AINVLKAHGKSARESVLIPG 216

Human   210 LVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKLVKAERKFIEDRVQKI 274
            ..|:.......|.|::.:|.|...:.||:..|.::.........::.|.:...|....::|:..|
  Fly   217 YALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDITKERINMI 281

Human   275 IDLKDKVCAQSNKGF-VVINQKGIDPFSLDSLAKHGIVALRRAKRRNMERLSLACGGMAVNSF-- 336
            :          ..|. ||:...|:|...:....:.|.:|:||.|:.:::.::.|.|...:.|.
  Fly   282 L----------GTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITSLTN 336

Human   337 ----EDLTVDCLGHAGLVYEYTLGEEKFTFIEECVNPCSVTLLVKGPNKHTLTQVKDAIRDGLRA 397
                |......:|.|..|.:..:.:::...|:......:.:::::|||.....:::.::.|.|..
  Fly   337 MDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSVHDALCV 401

Human   398 IKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQET 462
            :|..:|...:|.|.|.:|.|::..|..:..|:..|.:|.:..||.:||:|||.|:.||..|..:.
  Fly   402 VKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAKDATDL 466

Human   463 LVKVQAEHVESK--------QLVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVD 519
            :.|:::.|..|:        :..|:||..|.......|||.:....|.:.|...|..|..||.:|
  Fly   467 VAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAITILRID 531

Human   520 EIMR 523
            ::::
  Fly   532 DMIK 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	135/524 (26%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	135/524 (26%)