Protein Alignment CCT6B and CCT5

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_523707.1
• Gene: CCT5 / 36308
• FlyBaseID: FBgn0010621
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 163/531 - (30%)
• Similarity: 274/531 - (51%)
• Gaps: 58/531 - (10%)

Human    19 ALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAKVATA 83
            |:..:|.|||.:...|:|:|||||..|::||..||:.:|.||..::..|::.|..|.|:.:::.:
  Fly    34 AIKTHIMAARQIASTLKTSLGPKGLDKIMVSPDGDVTVTNDGATIMKLMEVDHEIAKLMVQLSQS 98

Human    84 QDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAA---KIKALEVLEEVKVTKEMKR 145
            |||..|||||..|::.|.||:||:..|..|:||..||:|||.|   .||.|:.:.:........:
  Fly    99 QDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIRIADGFELAAQCAIKQLDAIAQPFPVDPKNK 163

Human   146 KILLDVARTSLQTKV----HAELADVLTEVVVDSVLAVRRPGYPIDL----FMVEIMEMKHKLG- 201
            :.|:.:|.|:|.:|:    |.::|    |:.||:||.|      .|:    ...|:::::.|:|
  Fly   164 EPLIQIAMTTLGSKIVNKCHRQMA----EMAVDAVLNV------ADIEKKDVNFELIKIETKVGG 218

Human   202 --TDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLE------YEKTEVNSGFFYKTAEEKEK 258
              .|:.|::|:::|....|..|.|.:.:..:.|.....|      ..|.:|.|...|:...|.|
  Fly   219 RMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDVTSAEDYRALREYE- 282

Human   259 LVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGIVALRRAKRRNMER 323
                :.||    .|.:..:||....      :.|.|.|.|..:...|.:..:.|:|......:|.
  Fly   283 ----QEKF----TQMVKQVKDAGAT------LAICQWGFDDEANHLLLQQELPAVRWVGGPEIEL 333

Human   324 LSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLG--EEKFTFIEECVNPCSVTLLVKGPNKHTLTQ 386
            :::|.||..|..||:||.:.||.||||.|...|  ::|...||||.|..:||:.::|.|...:.:
  Fly   334 IAIATGGRIVPRFEELTPEKLGVAGLVREMAFGTSKDKMLVIEECKNSKAVTIFLRGGNAMIIAE 398

Human   387 VKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVL 451
            .|.:|.|.:..:::.::|..:|.|.||.|::.:.|:....:.:....:...:||:.||..||..|
  Fly   399 AKRSIHDAICVVRSLVKDSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPLAL 463

Human   452 AQNAGYDPQETLVKVQAEHV-ESKQLVGVDLNTGEPMVAADAGVWDNYCV-----KKQLLHSCTV 510
            |:|:|..|.|||.:::|..| |.|..:|||.     |::.|:.:..:..|     |||.:...|.
  Fly   464 AENSGLHPIETLSELKARQVAEKKSSLGVDC-----MLSGDSDMKSHNVVESLHSKKQQILLSTQ 523

Human   511 IATNILLVDEI 521
            :...||.:|::
  Fly   524 LVKMILKIDDV 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	163/531 (31%)
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	163/531 (31%)