Protein Alignment CCT6B and CCT4

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_609579.1
• Gene: CCT4 / 34674
• FlyBaseID: FBgn0032444
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 158/534 - (29%)
• Similarity: 282/534 - (52%)
• Gaps: 35/534 - (6%)

Human     5 KAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQI 69
            ||...|::....|.:   ||.||:.:.|.:||:|||:|..||:.:|.|::.:|.||..:|.:|.:
  Fly    15 KAFKDKSKPTDVRLS---NIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNV 76

Human    70 QHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVL 134
            .||.|.::.:::.|||...||||||.|:|.|.||:..:..:.:||||..|::.|:....||:|:|
  Fly    77 LHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEIL 141

Human   135 EEVKVTKEM-KRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPG--YPIDLFMVEIMEM 196
            :::....|: .|:.|:..|.|||.:||.::.:.:|..:.||:||.|..||  ..:||..::::..
  Fly   142 KQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISS 206

Human   197 KHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKLVK 261
            ......||:|:.|||....:...:..||:|.|.|.:....:...||:::...........::::|
  Fly   207 LGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLK 271

Human   262 AERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGI-----VALRRAKRRNM 321
            .||.:|.:.|::|   |...|.      |::.||.|...::..||:|.:     :.::..:|.::
  Fly   272 EERSYILNIVKQI---KKSGCN------VLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDI 327

Human   322 ERL--SLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVN-PCSVTLLVKGPNKHT 383
            |.:  :|.|..:|  |.:..|.:.|..|.||.|...|..||..|....| ..:|:::.:|.||..
  Fly   328 EFVCKTLHCRPIA--SLDHFTAENLSSADLVEEVASGTNKFVKITGIQNMGRTVSIICRGSNKLV 390

Human   384 LTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIP 448
            |.:...::.|.|..::..::....:.|.||.|:.||..|.....:::|......:||||||.:||
  Fly   391 LEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIP 455

Human   449 KVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKKQLLH-SCTVIA 512
            ..||:|||.:|..|:.:::..|.:.::..|:::..|     |...::....|:..|:. |...:|
  Fly   456 STLAENAGLNPIATVTELRNRHAQGEKNAGINVRKG-----AITDIFAENVVQPLLVSISSITLA 515

Human   513 T----NILLVDEIM 522
            |    :||.:|:|:
  Fly   516 TETIRSILKIDDIV 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	158/534 (30%)
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	156/531 (29%)