Protein Alignment CCT6B and Hsp60A

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 137/582 - (23%)
• Similarity: 230/582 - (39%)
• Gaps: 127/582 - (21%)

Human     5 KAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQI 69
            |.|....|| ||.....|::     |.|.:...:||||...::....|..|:||||..:...:::
  Fly    24 KDVRFGPEV-RAMMLQGVDV-----LADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIEL 82

Human    70 ----QHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKA 130
                |:..|.|:..||...::..|||||:..::...:.|:....||:|.:|..|..|...|
  Fly    83 KDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLA---- 143

Human   131 LEVLEEVKVT-KEMKRKILLDVARTSLQTKVHAELADVLT----------EVVVDSVLAVRRPGY 184
               :|.||.. |.|.|.:           ....|:|.|.|          .::.:::..|.|.|
  Fly   144 ---VETVKDNLKTMSRPV-----------STPEEIAQVATISANGDQAIGNLISEAMKKVGRDG- 193

Human   185 PIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFF 249
                 ::.:.:.| .|..:.::|:|:..|.|...|..                      :||...
  Fly   194 -----VITVKDGK-TLTDELEVIEGMKFDRGYISPYF----------------------INSSKG 230

Human   250 YKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLA----KHGI 310
            .|...:...|:.:|:|.  ..||.||...:...|| .|..|:| .:.||..:|.:|.    |.|:
  Fly   231 AKVEFQDALLLLSEKKI--SSVQSIIPALELANAQ-RKPLVII-AEDIDGEALSTLVVNRLKIGL 291

Human   311 -VALRRA------KRRNMERLSLACGGMAVN------SFEDLTVDCLGHAGLV------------ 350
             ||..:|      ::..:..:::|.||:...      ..||:.|..||..|.|
  Fly   292 QVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKG 356

Human   351 -----------------YEYTLGE-EKFTFIEECVNPCS-VTLL-VKGPNKHTLTQVKDAIRDGL 395
                             .|.|..| ||....|......| |.|| |.|.::..:.:.||.:.|.|
  Fly   357 KGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDAL 421

Human   396 RAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQ 460
            .|.:.|:|:| :|||.|...:...|.|...:.:.:.: :|||:....||.:....:|:|||.|..
  Fly   422 NATRAAVEEG-IVPGGGTALLRCIEKLEGVETTNEDQ-KLGVEIVRRALRMPCMTIAKNAGVDGA 484

Human   461 ETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIM 522
            ..:.||:.:..:    .|.|...||.....:.|:.|...|.:..:...:.:|:.:...:.::
  Fly   485 MVVAKVENQAGD----YGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVV 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	137/582 (24%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	137/582 (24%)