Protein Alignment CCT6B and CCT2

DIOPT Version :10

• Sequence 1: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Sequence 2: NP_572524.1
• Gene: CCT2 / 31838
• FlyBaseID: FBgn0030086
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 153/543 - (28%)
• Similarity: 293/543 - (53%)
• Gaps: 51/543 - (9%)

Human     4 IKAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVS---GAGDIKLTKDGNVLLD 65
            ::.:.::|:..:|..|...:...|..:.|::::.|||||..|:||:   .||.:::|.||..:|.
  Fly     8 VRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILR 72

Human    66 EMQIQHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKA 130
            .:.:.:|.|.::..::..||:..||||||..::..|||::|:..:.:.|||:||..|:..|...|
  Fly    73 AVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWRQATQVA 137

Human   131 LEVL----EEVKVTKEMKRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPGYPIDLFMV 191
            ||.|    ::...:.|..|..||::|||:|.:|:..:..|....:.||:|:.::..|   :|..:
  Fly   138 LEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSG---ELKSI 199

Human   192 EIMEMKHKLGT--DTKLIQGLVLDH--GARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKT 252
            :|  :|...||  |:.|.:|.:||.  |...|   :|:|:|.|||.|..::.:|.:|     :.:
  Fly   200 QI--IKKSGGTLGDSFLDEGFLLDKKPGVHQP---QRIENARILIANTPMDTDKIKV-----FGS 254

Human   253 AEEKEKLVK------AERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGIV 311
            :.:.:.|.|      ||::.::::|.||:         .:|..|.||::.|..:.....|...::
  Fly   255 SIKVDSLAKIADLEMAEKEKMKEKVDKIL---------KHKCNVFINRQLIYNYPEQLFADARVM 310

Human   312 ALRRAKRRNMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEE---KFTFI---EECVNPC 370
            ::..|....:|||:...||..|::||:.::..||...::.:..:||:   :|:.:   |.|
  Fly   311 SIEHADFDGIERLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEAC---- 371

Human   371 SVTLLVKGPNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARL 435
              |::::|..:..|.:...::.|.|..:...:::..::.|.|..|..||.|::.......|:..:
  Fly   372 --TIVIRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAI 434

Human   436 GVQAFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCV 500
            .::|||.|||.:|..:|.|||||..:.:.:::|.|.:.||.:|:|:..|:.....:.|:.:::.|
  Fly   435 AIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAV 499

Human   501 KKQLLHSCTVIATNILLVDEIMR 523
            |:|:|.|.:..|..||.||.|:|
  Fly   500 KRQVLMSASEAAEMILRVDNIIR 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	153/543 (28%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	153/541 (28%)