DRSC/TRiP Functional Genomics Resources

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Protein Alignment DLL3 and Dl

DIOPT Version :9

Sequence 1:NP_058637.1 Gene:DLL3 / 10683 HGNCID:2909 Length:618 Species:Homo sapiens
Sequence 2:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster


Alignment Length:649 Identity:181/649 - (27%)
Similarity:250/649 - (38%) Gaps:156/649 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    13 TVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARL---------PCRLFFRVCLKPGL 68
            |..:....:.|...:|.|||::..|....|.......||...         .|:..||||||...
  Fly     9 TAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQ 73

Human    69 SEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGL----------LQVPFRDAWPGTFSFI 123
            :.....|.|..|..::   |:..|.      .:.|.|..          :|.||..:||||||.|
  Fly    74 ATIDTTSQCTYGDVIT---PILGEN------SVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLI 129

Human   124 IETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACT 188
            :|.|.:............|:.|:..::.|.....|..:...:....|.:.:|..|:....|:.|.
  Fly   130 VEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCA 194

Human   189 RLCRPR------SAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247
            :.||||      |..|..|..:.......|.|..| .|..||  |||.|::|.:|.|..||.|.|
  Fly   195 KFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIP-KCAKGC--EHGHCDKPNQCVCQLGWKGAL 256

Human   248 CTVPVSTSSCL---------------------------------SPRGPSSATTG-------CLV 272
            |...|...:|:                                 ...|.:...||       |  
  Fly   257 CNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKC-- 319

Human   273 PGPG-----------PCDG--NPCANGGSCSETPRS---FECTCPRGFYGLRCEVSGVTCADGPC 321
             .||           .||.  |||.|||:|.:.|.:   ::|.|..|:.|..||...:||:|.||
  Fly   320 -APGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC 383

Human   322 FNGGLC----VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAG 382
             :.|:|    .|.......|.|.||.|:.|.||:.::|.||..||.|||.|...|   :|.|.||
  Fly   384 -HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSG---KCICPAG 444

Human   383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCY-- 445
            |:|.|||.::|||.|..|.|||||::....:||.|..||.|..|..:.|.|..||||:||.|.  
  Fly   445 FSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNL 509

Human   446 ---------AHFSG---------------------------LVCACAPGYMGARCE--------F 466
                     |.|:|                           ..|.||.|:.|.:|:        |
  Fly   510 NNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTF 574

Human   467 PVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQ---DAGSR 527
            ..|..||:. .|...||.  :.|..|:......:....|..|.::....|:|..:|   ||.:|
  Fly   575 DAHQYGATT-QARADGLT--NAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEAR 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DLL3NP_058637.1 MNNL 27..84 CDD:284966 18/65 (28%)
DSL 158..248 CDD:302925 29/95 (31%)
EGF_CA 279..310 CDD:238011 13/35 (37%)
EGF 316..349 CDD:278437 13/36 (36%)
EGF_CA 354..389 CDD:238011 17/34 (50%)
EGF_CA 391..426 CDD:238011 16/34 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..566
DlNP_001247193.1 MNNL 23..96 CDD:284966 20/81 (25%)
DSL 164..226 CDD:279722 14/61 (23%)
EGF_CA 291..329 CDD:238011 6/40 (15%)
EGF_CA 337..372 CDD:238011 12/34 (35%)
EGF_CA 453..488 CDD:238011 16/34 (47%)
EGF_CA 492..526 CDD:238011 12/33 (36%)
EGF_CA 529..564 CDD:238011 5/34 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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