DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DLL3 and shf

DIOPT Version :9

Sequence 1:	NP_058637.1	Gene:	DLL3 / 10683	HGNCID:	2909	Length:	618	Species:	Homo sapiens
Sequence 2:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	99/364 - (27%)
Similarity:	131/364 - (35%)	Gaps:	133/364 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   117 PGTFSFIIETWREELGDQIGGPAWSLLARVAGRRR---------------LAAGGPWARDIQRAG 166
            |...:::..||:                  :|||:               |.|.....|...|..
  Fly   166 PSEVNYVNFTWK------------------SGRRKYFYDFDRLQTMDESILKAPTLSIRKSGRIP 212

Human   167 AWELRFSYRARCEPPAVGTAC--------TRLCRPRS-APSRCGPGLRPCAPLEDEC-------- 214
            ..:..||....|...:.|||.        ||..:|.| .|.|..        .:.||
  Fly   213 QEQKNFSIFLPCTGNSSGTASFNVGLKIQTRHNKPLSGTPIRLN--------FKKECAHRGVYDI 269

Human   215 -----------EAP-LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSAT 267
                       :|| ..|...|. ::|:|.:...|:|..|:||..|    .|:.|. |:
  Fly   270 DASNPTSLTTLQAPDPECSLKCG-KNGYCNEHHICKCNVGYTGQYC----ETAFCF-PQ------ 322

Human   268 TGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD 332
                           |.|||:|:...   .||||.|:.|.:||  |..|.| .|.|||.|:   .
  Fly   323 ---------------CLNGGNCTAPS---VCTCPEGYQGTQCE--GGICKD-KCLNGGKCI---Q 363

Human   333 PDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG 397
            .|.   |.|..|:.|..||  ..:|.: ||:|.|.|  :|:.| |||..|..|..||      .|
  Fly   364 KDK---CQCSKGYYGLRCE--YSKCVI-PCKNEGRC--IGNNL-CRCPNGLRGDHCE------IG 413

Human   398 R------ACANGGTCVEGGGAHR-CSCALGFGGRDCRER 429
            |      .|.| ||||    :|: |.|..||.||.|..|
  Fly   414 RKQRSICKCRN-GTCV----SHKHCKCHPGFYGRHCNGR 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLL3	NP_058637.1	MNNL	27..84	CDD:284966
		DSL	158..248	CDD:302925	27/118 (23%)
		EGF_CA	279..310	CDD:238011	11/30 (37%)
		EGF	316..349	CDD:278437	12/32 (38%)
		EGF_CA	354..389	CDD:238011	13/34 (38%)
		EGF_CA	391..426	CDD:238011	15/41 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566
shf	NP_001284963.1	WIF	137..258	CDD:280237	22/117 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910