Protein Alignment DLL3 and Dll3

DIOPT Version :10

• Sequence 1: NP_058637.1
• Gene: DLL3 / 10683
• HGNCID: 2909
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_446118.2
• Gene: Dll3 / 114125
• RGDID: 70953
• Length: 589
• Species: Rattus norvegicus
• Alignment Length: 590
• Identity: 488/590 - (82%)
• Similarity: 520/590 - (88%)
• Gaps: 6/590 - (1%)

Human     1 MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLK 65
            |||.::|. |.||:|||.: |||..|||||||||||||||||||.|||||:||.|||||||||||
  Rat     1 MVSLQVSS-LPQTLILAFL-LPQALPAGVFELQIHSFGPGPGPGTPRSPCNARGPCRLFFRVCLK 63

Human    66 PGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIETWREE 130
            ||:|:|||||.||||||||..|||||||||.||..|.|||||::||||||||||||.|||||||:
  Rat    64 PGVSQEAAESLCALGAALSTSGPVYTEQPGVPAAALSLPDGLVRVPFRDAWPGTFSLIIETWREQ 128

Human   131 LGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCRPRS 195
            ||::..||||:||||||||||||||.|||||:||.|||||.|||||||||||||.||.||||.||
  Rat   129 LGERAAGPAWNLLARVAGRRRLAAGAPWARDVQRTGAWELHFSYRARCEPPAVGAACARLCRSRS 193

Human   196 APSRCGPGLRPCAPLEDECEAP----LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSS 256
            ||||||||||||.|..||||||    .|||||||||||:||:|.||.||||||||||||||||||
  Rat   194 APSRCGPGLRPCTPFPDECEAPRESLTVCRAGCSPEHGYCEEPDECHCLEGWTGPLCTVPVSTSS 258

Human   257 CLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
            ||:.|....|.||||:|||||||||||||||||||||.||||.|||||||.||||||||||||||
  Rat   259 CLNSRVSGPAGTGCLLPGPGPCDGNPCANGGSCSETPGSFECACPRGFYGPRCEVSGVTCADGPC 323

Human   322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGP 386
            |||||||||.||||||:|||||.|||||||:||||||||||:|||||||||||||||||||||||
  Rat   324 FNGGLCVGGEDPDSAYVCHCPPAFQGSNCERRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGP 388

Human   387 RCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGL 451
            ||||||||||||||||||||||||||.|||||||||||||||||||||:||||||||||||||||
  Rat   389 RCEHDLDDCAGRACANGGTCVEGGGARRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGL 453

Human   452 VCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVR 516
            ||||||||||.||||.|.||||.|:||||.|||..|.||:|||||||||.||.:|||||||:|||
  Rat   454 VCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADSQRFLLPPALGLLAAAALAGAALLLIHVR 518

Human   517 RRGHSQDAGSRLLAGTPEPSVHALPDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPS 581
            |||..:|.|:|||:||.|||||.|||||||||.|:|:|||||||.|||.|||.|.:.||||.|||
  Rat   519 RRGPGRDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPS 583

Human   582 IYARE 586
            |||||
  Rat   584 IYARE 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DLL3	NP_058637.1	MNNL	27..175	CDD:462222	122/147 (83%)
		DSL	158..248	CDD:473190	75/93 (81%)
		EGF_CA	279..310	CDD:238011	27/30 (90%)
		EGF	316..349	CDD:394967	29/32 (91%)
		EGF_CA	354..389	CDD:238011	33/34 (97%)
		EGF_CA	391..426	CDD:238011	33/34 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	546..566		15/19 (79%)
Dll3	NP_446118.2	MNNL	25..173	CDD:462222	122/147 (83%)
		EGF_CA	281..312	CDD:238011	27/30 (90%)
		EGF_CA	356..391	CDD:238011	33/34 (97%)
		EGF_CA	393..428	CDD:238011	33/34 (97%)
		EGF_CA	433..467	CDD:238011	31/33 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	552..574		16/21 (76%)