DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BUB1B-PAK6 and CLA4

DIOPT Version :9

Sequence 1:	NP_001122100.1	Gene:	BUB1B-PAK6 / 106821730	HGNCID:	52276	Length:	681	Species:	Homo sapiens
Sequence 2:	NP_014101.1	Gene:	CLA4 / 855418	SGDID:	S000005242	Length:	842	Species:	Saccharomyces cerevisiae

Alignment Length:	740	Identity:	223/740 - (30%)
Similarity:	335/740 - (45%)	Gaps:	163/740 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    12 ISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITR----------VQLQP 66
            :|:|.||.|:||..|||:.|.|||:|..|:.:|          ..||||.          :|:..
Yeast   184 VSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLL----------KHSRITGEDWNNNSAAVIQVLQ 238

Human    67 MKTVVRGSAMP---VDGYISGLLNDIQKL--SVISSNTLRGRSPTSRRRA-QSLGLLGDEHWATD 125
            ......|:..|   :|...||..:..||.  :..:.|.||..|..|:..: .|..::.....:..
Yeast   239 FYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQP 303

Human   126 PDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVL---PNGLAAKAQS-------- 179
            |:  .:||.|          ..:|..|..:.::|..:...||.|   ||....|.::
Yeast   304 PN--TKSPVS----------LGSGSLPPINTKLPTSQSNIPRHLQNVPNQQYPKMRNGHSPTNGQ 356

Human   180 --LGPAEFQGASQRCLQLGACLQS----------------SPPGASPPTGTNRHGMKAAKHGSEE 226
              .||.. ...|||.||.....|.                ||..:..|:..|.:
Yeast   357 FPRGPMH-PNNSQRSLQQQQQQQQQQKQQHQQYPYHHQGPSPSPSPSPSPLNPY----------- 409

Human   227 ARPQSCLVGSATGRPGGEGSP--SPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNS 289
             ||...::...:.:|   .||  |..|:..::.|....|.  .|||...|..:.| .||.|.|.:
Yeast   410 -RPHHNMINPYSKQP---QSPLSSQSTQNQAIPRYAQNSS--PTAAHFQPQRTAP-KPPISAPRA 467

Human   290 SFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGR--SSPAG-- 350
            .:  |...|       |.|....|||.     ..:|.|:|| ::|.||   :.|..  :.|.|
Yeast   468 PY--PSNQN-------ATSNTHVQPVA-----PKNDQSTPQ-TMRQAP---KRPDADVAQPGGVA 514

Human   351 SPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGE 415
            .|:.            |..||::..             :..:.|:.|....||........|.|:
Yeast   515 KPKK------------PARPTMSTA-------------EIMSKLKKVTVNADPSQCFKVIEKAGQ 554

Human   416 GSTGIVCLAR-------------------EKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQH 461
            |::|.|.||.                   |.|.|.:||:|.|.|.||.|:||:.||:::|:|.:|
Yeast   555 GASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRH 619

Human   462 FNVVEMYKSYL-VGEELWVLMEFLQGGALTDIV--------SQVRLNEEQIATVCEAVLQALAYL 517
            .|:|...::|| ..::|||:|||::||:||||:        |...|.|.|||.:.....|.|.:|
Yeast   620 KNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFL 684

Human   518 HAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEV 582
            |.:.:||||||||::||....|||::||||||:::....||.::|||||||||||:.:..|..::
Yeast   685 HDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKI 749

Human   583 DIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERA 647
            |:||||||.|||::|||||.::.|::|:..:..:..||||:...:|..::.||...|..|.:.||
Yeast   750 DVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRA 814

Human   648 TAQELLDHPFLLQTGLPECLVPLIQ 672
            :.:|||.|.|......|:.|..|::
Yeast   815 STEELLHHGFFNMACDPKDLTSLLE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BUB1B-PAK6	NP_001122100.1	PBD	11..67	CDD:307091	22/64 (34%)
BUB1B-PAK6	NP_001122100.1	STKc_PAK6	385..681	CDD:270821	124/316 (39%)
CLA4	NP_014101.1	PH_Cla4_Ste20	62..174	CDD:270097
		PBD	183..241	CDD:395634	22/66 (33%)
		STKc_PAK	546..826	CDD:270789	117/279 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910