Protein Alignment GNA13 and Galphas

DIOPT Version :10

• Sequence 1: NP_006563.2
• Gene: GNA13 / 10672
• HGNCID: 4381
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 377
• Identity: 136/377 - (36%)
• Similarity: 195/377 - (51%)
• Gaps: 41/377 - (10%)

Human    27 QQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSN 91
            |:|:|..|.:.|.::|...:...::||||||||||||.:|||||:|...|....:::....|..|
  Fly    22 QKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIKKN 86

Human    92 VIKGMRVLVDAREKLHIPWGDNSNQQH------GDKMMSFDTRAPMAAQGMVETRVFLQYLPAIR 150
            :...:..:..|...|:.|......:..      .|...|.|...|.            ::.....
  Fly    87 IRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPP------------EFYEHTE 139

Human   151 ALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKN 215
            .||.|.|:...|:|..|:||.:..|||||.:..:..|:|.|::||||..|..|.||.|..|::..
  Fly   140 ELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDK 204

Human   216 VPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRV 280
            |.|.|.||||||.||::|.:||:.||:|:|:.:.|.::.||.||...|||.|||::|::|.|||.
  Fly   205 VNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRW 269

Human   281 FSNVSIILFLNKTDLLEEKVQI--VSIKDYFLEF----------------EGDPHCLRDVQKFLV 327
            ...:||||||||.|||.||::.  ..:.:||.||                ..||..:|  .|:.:
  Fly   270 LRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIR--AKYFI 332

Human   328 --ECFRNKRRDQQQKP-LYHHFTTAINTENIRLVFRDVKDTILHDNLKQLML 376
              |..|........|. .|.|||.|::||||:.||.|.:|.|...:|:|..|
  Fly   333 RDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA13	NP_006563.2	G_alpha	29..375	CDD:214595	134/372 (36%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	50..63		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	195..203		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	218..227		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	287..294		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	347..352		2/4 (50%)
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	127/348 (36%)