Protein Alignment GNA13 and Galphaq

DIOPT Version :10

• Sequence 1: NP_006563.2
• Gene: GNA13 / 10672
• HGNCID: 4381
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 165/404 - (40%)
• Similarity: 234/404 - (57%)
• Gaps: 56/404 - (13%)

Human    18 CLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRARE 82
            |.|:....||:|.::||:|.|.|:|...:|.:|:||||.||||||||:||||||||..:....:.
  Fly     3 CCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKR 67

Human    83 EFRPTIYSNVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQ--Y 145
            .:...::.|:...|:.::.|.:.|.|.:|...:.:..|.:||.|          .||....:  |
  Fly    68 GYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSID----------YETVTTFEDPY 122

Human   146 LPAIRALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEP----------------------- 187
            |.||:.||.|:|||..||||||:||.:|.||:|.:||::.:|
  Fly   123 LNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYP 187

Human   188 --------------------DYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKR 232
                                ||:|::||||.||.||.||.||.|::..:.|:|||||||||||::
  Fly   188 FDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRK 252

Human   233 WFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLE 297
            |..||::||||:|||:.||:||:|.|....||:.||..:|.||:....|.|.|:||||||.||||
  Fly   253 WIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLE 317

Human   298 EKVQIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFRDV 362
            ||:....:.|||.|::|........::|::..|.:...| .:|.:|.|||.|.:||||:|||..|
  Fly   318 EKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPD-SEKIIYSHFTCATDTENIKLVFCAV 381

Human   363 KDTILHDNLKQLML 376
            ||||:.:.||:..|
  Fly   382 KDTIMQNALKEFNL 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNA13	NP_006563.2	G_alpha	29..375	CDD:214595	160/390 (41%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	50..63		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	195..203		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	218..227		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	287..294		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	347..352		2/4 (50%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	150/366 (41%)