DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD226 and cd226

DIOPT Version :9

Sequence 1:	NP_001290547.1	Gene:	CD226 / 10666	HGNCID:	16961	Length:	336	Species:	Homo sapiens
Sequence 2:	NP_001074115.1	Gene:	cd226 / 791164	ZFINID:	ZDB-GENE-070112-1322	Length:	344	Species:	Danio rerio

Alignment Length:	340	Identity:	92/340 - (27%)
Similarity:	160/340 - (47%)	Gaps:	33/340 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     3 YPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTH 67
            |..:|:.||...:...:.....:||...|.|.|:|:.|..|.|..|.|.|....: .||::.|.:
Zfish    10 YFLVLVMLLCFLKGSVQMKAPESSVVLQEGMVLDCLCPWTGQLIMVSWTKTPFAK-PIAVYHPQY 73

Human    68 GMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQK---VIQVVQSDS 129
            |......|..||.||.||....::::.  |.:|.|:|.|.|||.|||||:|.|   |.:...:.|
Zfish    74 GTNFGSSYEGRVEFLKSTAMDGSISIM--NVTEGDIGQYHCSLQTYPQGSWTKDTFVQKAAITTS 136

Human   130 FEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQ--IDLLTYCNL----VHGRNFT 188
            ...::.:::.:|.....|:|:.|.......:..|..||:...:  .:::..|.:    |..|||:
Zfish   137 TSISIQADTKLVVAENDNLTIMCDLVHDGKIYQVSIEKLDTEEGNSNIIATCEMLEDGVELRNFS 201

Human   189 SKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTV-AEGKTDNQYTLF 252
            ::.    :.|||......:.:.::...|.|||||....:.|...|.|:..|| |:......:.|:
Zfish   202 NRG----LLNCSEDMEVSLHLTNIIKEDGGLYRCNFSTNNGIQSTTVLLTTVPAQDFPGLHHMLY 262

Human   253 V-AGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAP-NNYRSPISTSQPTNQSMD 315
            | .||.|   :.|:::.|:::.:|||.:|::      |.:..:..| ...|:|...|...::...
Zfish   263 VYIGGGV---IGVVALMTLLLTWLNRMKRKK------EEYRIKLHPAKRQRNPYDQSCVYDRMKK 318

Human   316 DTR-----EDIYVNY 325
            .||     ::||:|:
Zfish   319 GTRTRAKDKEIYMNF 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD226	NP_001290547.1	Ig	31..127	CDD:299845	37/98 (38%)
		Ig	136..240	CDD:299845	24/109 (22%)
		IG_like	138..240	CDD:214653	24/107 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		4/19 (21%)
cd226	NP_001074115.1	Ig1_DNAM-1_like	38..131	CDD:143297	37/95 (39%)
		IG_like	147..247	CDD:214653	24/103 (23%)
		Ig	<200..247	CDD:299845	13/50 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339027
Domainoid	1	1.000	68	1.000	Domainoid score	I32359
eggNOG	1	0.900	-	-		E1_2CDUK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4787
Inparanoid	1	1.050	109	1.000	Inparanoid score	I12138
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40051
OrthoDB	1	1.010	-	-		D271057at7742
OrthoFinder	1	1.000	-	-		FOG0009213
OrthoInspector	1	1.000	-	-		oto49232
orthoMCL	1	0.900	-	-		OOG6_120459
Panther	1	1.100	-	-	LDO	PTHR47011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270