DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD226 and DIP-iota

DIOPT Version :9

Sequence 1:	NP_001290547.1	Gene:	CD226 / 10666	HGNCID:	16961	Length:	336	Species:	Homo sapiens
Sequence 2:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	64/266 - (24%)
Similarity:	94/266 - (35%)	Gaps:	82/266 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    24 HTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPY-------AERVYF 81
            :::||...:..|.||...: :..:|.|.::.||    .|.| ....||.|.:       ..|::.
  Fly    39 NSTVPVGRDALLTCVVHDL-VSFKVAWLRVDTQ----TILS-IQNHVITKNHRISISHTEHRIWQ 97

Human    82 LNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVP-------SNSH 139
            |.           .|:..|.|.|:|.|.:.|.|..:....:.||        ||       ::..
  Fly    98 LK-----------IRDVQESDRGWYMCQINTDPMKSQMGYLDVV--------VPPDIVDYQTSQD 143

Human   140 IVSEPGKNVTLTC------QPQMTWPVQAVRWEKIQPRQI----DLLTYCNLVHGRNFTSKFPRQ 194
            :|...|:||||||      .|.:||     |.|:..|..|    |...:.  |.|:|.|
  Fly   144 VVRSTGQNVTLTCSATGVPMPTITW-----RREEATPILISDDGDREVFS--VEGQNLT------ 195

Human   195 IVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQY----TLFVAG 255
                    .|      .|..|..|.|.|.  ||.|...|...|:.:........:    |::|..
  Fly   196 --------LW------QVQRSHMGAYLCI--ASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGL 244

Human   256 GTVLLL 261
            |..|.|
  Fly   245 GQKLTL 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD226	NP_001290547.1	Ig	31..127	CDD:299845	24/102 (24%)
		Ig	136..240	CDD:299845	31/113 (27%)
		IG_like	138..240	CDD:214653	31/111 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	24/102 (24%)
		Ig	39..122	CDD:299845	24/99 (24%)
		Ig	132..213	CDD:299845	28/109 (26%)
		IG_like	141..227	CDD:214653	31/114 (27%)
		IG_like	239..322	CDD:214653	5/12 (42%)
		IGc2	245..313	CDD:197706	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910