DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD226 and DIP-eta

DIOPT Version :9

Sequence 1:	NP_001290547.1	Gene:	CD226 / 10666	HGNCID:	16961	Length:	336	Species:	Homo sapiens
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	74/395 - (18%)
Similarity:	134/395 - (33%)	Gaps:	129/395 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    26 SVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNN 90
            :.|...:..|.||...:|.. :|.|.::.||    .|.:..:.::.:.   :|:...||  ....
  Fly    53 TAPVGRDAFLTCVVQDLGPY-KVAWLRVDTQ----TILTIQNHVITKN---QRIGIANS--EHKT 107

Human    91 MTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQ-VVQSDSFEAAVPSNSHIVSEPGKNVTLTC-- 152
            .|:..::..|.|.|:|.|.:.|.|..:....:. ||..|..:  .|:::.:|...|.||||.|
  Fly   108 WTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPDILD--YPTSTDMVVREGSNVTLKCAA 170

Human   153 ----QPQMTW------PVQAVRWEKIQ--------------------------------PRQIDL 175
                :|.:||      |::....|::.                                .::|.|
  Fly   171 TGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITL 235

Human   176 LTY-----------CNLVHGRNFT-----SKFPR----------QIVSNCSHGRWSVIV------ 208
            :.:           ...|.|:..|     ..:|:          :||.  ..|::|..|
  Fly   236 VVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVP--PGGKYSANVTEIGGY 298

Human   209 -------IPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVIS 266
                   |..:|.::.|.|||..:.|.|:.:                       ||:.|.....:
  Fly   299 RNSMRLHINPLTQAEFGSYRCVAKNSLGDTD-----------------------GTIKLYRIPPN 340

Human   267 ITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMD-----DTREDIYVNYP 326
            ....:..| ..|.:.::|...:||....:|..:  |......|..:..|     ::.:.||.|..
  Fly   341 AVNYVENF-EARHKGKKRTKSSESHHPARAQEH--SGEDMENPGKRKADLSLGAESIDSIYGNSA 402

Human   327 TFSRR 331
            ..|||
  Fly   403 AGSRR 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD226	NP_001290547.1	Ig	31..127	CDD:299845	22/96 (23%)
		Ig	136..240	CDD:299845	31/186 (17%)
		IG_like	138..240	CDD:214653	31/184 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		3/23 (13%)
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/97 (22%)
		IG_like	51..137	CDD:214653	21/93 (23%)
		IG_like	153..237	CDD:214653	14/83 (17%)
		Ig	161..224	CDD:299845	11/62 (18%)
		IG_like	252..335	CDD:214653	19/107 (18%)
		Ig	258..333	CDD:143165	17/99 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910