DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD226 and Cd226

DIOPT Version :9

Sequence 1:	NP_001290547.1	Gene:	CD226 / 10666	HGNCID:	16961	Length:	336	Species:	Homo sapiens
Sequence 2:	NP_001100840.1	Gene:	Cd226 / 307199	RGDID:	1311513	Length:	346	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	176/338 - (52%)
Similarity:	228/338 - (67%)	Gaps:	9/338 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFK-IGTQQDSIAIFS 64
            |.|.|.|||:|||::|||||.||.|:|..:|.|:||||||....|||.||.| .||::.:||::.
  Rat    14 MAYLTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTDNLTQAEWTKDTGTKKVNIAVYH 78

Human    65 PTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDS 129
            |.|.|.|...|..||:|.|:|:...||:|.|.||||.|:|.|:|..:.:|:|:|:|.|:||||||
  Rat    79 PNHNMHIDPNYLHRVHFQNATVGFRNMSLSFYNASEADIGIYTCLFHAFPRGSWEKKIKVVQSDS 143

Human   130 FEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQ 194
            ||...|.:|::.:|||:||||:||.:.||.||.|.|||:||.|:|:|..|||..|..:|||:.||
  Rat   144 FETTAPLDSYLSAEPGQNVTLSCQLERTWLVQLVIWEKVQPHQVDILASCNLSQGTRYTSKYLRQ 208

Human   195 IVSNCS-HGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTV 258
            ..|:|| ....|.::||....:|||||||..:||.|.|:|.|:||.:.:|.|:|.:.|.:.||..
  Rat   209 TWSDCSQESMKSALIIPYAMAADSGLYRCRSEASTGTNKTCVIRLIITDGGTNNHFILLIVGGLA 273

Human   259 LLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQ-KAPNNYRSPISTSQPTNQSMDDTREDIY 322
            .||| ||.||.||::| ||:|||:.|....|..|.| |...|.|||.|..|.|    ||.:||||
  Rat   274 SLLL-VILITIIIILF-NRKRRRQVRTPLKELRDKQSKVATNCRSPTSPIQTT----DDEKEDIY 332

Human   323 VNYPTFSRRPKTR 335
            |||||||||||.|
  Rat   333 VNYPTFSRRPKPR 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD226	NP_001290547.1	Ig	31..127	CDD:299845	47/96 (49%)
		Ig	136..240	CDD:299845	53/104 (51%)
		IG_like	138..240	CDD:214653	53/102 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		7/18 (39%)
Cd226	NP_001100840.1	Ig1_DNAM-1_like	44..141	CDD:143297	47/96 (49%)
		Ig	151..239	CDD:299845	45/87 (52%)
		IG_like	152..255	CDD:214653	53/102 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691444
Domainoid	1	1.000	98	1.000	Domainoid score	I43273
eggNOG	1	0.900	-	-		E1_2CDUK
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4787
Inparanoid	1	1.050	333	1.000	Inparanoid score	I14214
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40051
OrthoDB	1	1.010	-	-		D144679at9347
OrthoFinder	1	1.000	-	-		FOG0009213
OrthoInspector	1	1.000	-	-		oto134681
orthoMCL	1	0.900	-	-		OOG6_120459
Panther	1	1.100	-	-	LDO	PTHR47011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X12996
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270