DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and CTCF

DIOPT Version :9

Sequence 1:	NP_006556.1	Gene:	CTCF / 10664	HGNCID:	13723	Length:	727	Species:	Homo sapiens
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	231/815 - (28%)
Similarity:	340/815 - (41%)	Gaps:	175/815 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    11 EESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQMVMMEQLDPTLLQMKT 75
            |:.:||:     ..:.:..||..:|..                ||:.::.:..|.:|  |.:...
  Fly    12 EDLQTFL-----NNFHKEIEGNSDEKV----------------VNTILEAISAEAID--LDENGA 53

Human    76 EVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYEN 140
            |........||||.:|..:       ..||:..:..:...:.......:.......:|||...:.
  Fly    54 EAGGSKPMEEAEADLDHAE-------EAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQ 111

Human   141 EVSKEGL------------------AESEPMICHTLPLPEGFQVVKVGANGEVETLEQGELPPQE 187
            ..:|.|.                  |:|.|....:.|.||...:....|.......:|..:||
  Fly   112 AAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPP-- 174

Human   188 DPSWQKDPDYQPPAKKTK------KTKKSKLRYTEEGKDV-----------DVS----------- 224
                       |||...|      :.:|:.:....|..|:           |:|
  Fly   175 -----------PPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTV 228

Human   225 ------------------VYDFEEEQQEGLLSEVNAEK-----VVGN----MKPPKPTKIKKKGV 262
                              ||:||:   .....:.||:|     |:.|    :|....|.......
  Fly   229 DEAAVEAATATLTPNEAEVYEFED---NATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNAS 290

Human   263 KKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDC 327
            ...:.|..|.||..::..:.||.:||..|...||.:|.|:||:...|:||:|||.|.:||||..|
  Fly   291 GHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLC 355

Human   328 DMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY 392
            :.||.||||||||.|||||.|||.||:.|.|||||::||:||:..||||||:||..|:|||:|.:
  Fly   356 ESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMF 420

Human   393 KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLR 457
            ||||||..|:|||.|:|.||.:|||||.::|.|.|.....:...|.|.:|.|...||:||.||::
  Fly   421 KLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIK 485

Human   458 KQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKP 522
            ..|: .:....||.|.....:||....|.|||:.||.:.|..|.||...:||:..|...|..|||
  Fly   486 HMHT-SDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKP 549

Human   523 YACSHCDKTFRQKQLLDMHFKRYHDPNFVP-----AAFVCSKCGKTFTRRNTMARHADNCAGPDG 582
            :.|..|.:.|||:|||..|....|:..:.|     ....|..|.:.||.:..:.||
  Fly   550 FHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRH--------- 605

Human   583 VEGENGGETKKSKRGR---KRKMRSKKEDS------SDSENAEPDLDDNEDEEEP----AVEIEP 634
            :|..:.....:.||.|   .|.:|.:|:.:      ....:.:.|.::||:::.|    ..||||
  Fly   606 METHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEP 670

Human   635 E-----------------PEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIE 682
            |                 |..|.:.|||....|:      ......:.||..|.|......|
  Fly   671 ENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQ------ARLAASEKQPMIINQRLRSQRG--- 726

Human   683 NIIVEVKKEPDAE--PAEGEEEEAQPAATDAPNGD 715
            .....:|:|||..  ..|.:.::.:....:..|||
  Fly   727 TKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGD 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_006556.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..211		8/36 (22%)
		zf-H2C2_5	266..289	CDD:404746	7/22 (32%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		zf-H2C2_2	280..305	CDD:404364	10/24 (42%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		zf-H2C2_2	309..333	CDD:404364	14/23 (61%)
		C2H2 Zn finger	324..347	CDD:275368	16/22 (73%)
		zf-H2C2_5	351..375	CDD:404746	13/23 (57%)
		C2H2 Zn finger	353..373	CDD:275368	11/19 (58%)
		COG5048	<366..500	CDD:227381	61/133 (46%)
		C2H2 Zn finger	381..401	CDD:275368	12/19 (63%)
		C2H2 Zn finger	409..426	CDD:275368	9/16 (56%)
		C2H2 Zn finger	439..457	CDD:275368	9/17 (53%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..534	CDD:404364	9/24 (38%)
		C2H2 Zn finger	525..546	CDD:275368	9/20 (45%)
		C2H2 Zn finger	557..573	CDD:275368	4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..677		27/133 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..717		8/29 (28%)
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	18/107 (17%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		COG5048	321..>621	CDD:227381	128/313 (41%)
		zf-C2H2	322..344	CDD:278523	15/21 (71%)
		C2H2 Zn finger	324..344	CDD:275368	13/19 (68%)
		zf-H2C2_2	337..361	CDD:290200	17/23 (74%)
		C2H2 Zn finger	352..373	CDD:275368	12/20 (60%)
		C2H2 Zn finger	381..401	CDD:275368	13/19 (68%)
		zf-H2C2_2	394..415	CDD:290200	14/20 (70%)
		C2H2 Zn finger	409..429	CDD:275368	10/19 (53%)
		zf-H2C2_2	422..446	CDD:290200	6/23 (26%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..561	CDD:290200	7/29 (24%)
		C2H2 Zn finger	552..573	CDD:275368	5/25 (20%)
		zf-C2H2	587..609	CDD:278523	6/24 (25%)
		C2H2 Zn finger	589..609	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAC7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2538
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40288
orthoMCL	1	0.900	-	-		OOG6_107263
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.750