Protein Alignment CTCF and ztf-2

DIOPT Version :10

• Sequence 1: NP_006556.1
• Gene: CTCF / 10664
• HGNCID: 13723
• Length: 727
• Species: Homo sapiens
• Sequence 2: NP_001379129.1
• Gene: ztf-2 / 184429
• WormBaseID: WBGene00008762
• Length: 360
• Species: Caenorhabditis elegans
• Alignment Length: 308
• Identity: 72/308 - (23%)
• Similarity: 97/308 - (31%)
• Gaps: 114/308 - (37%)

Human   353 CSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFT 417
            ||.|.|....||::.||.|.||.||||:|..||..|:....|.||
 Worm    89 CSTCGYQGKWVSEMIRHKRVHTSERPFKCRYCSRTSKWKADLIRH-------------------- 133

Human   418 QSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYAL 482
                            |||.|              |:.:..::|      :.:..||.
 Worm   134 ----------------VAKTH--------------GIRVVSKYS------RSKVFDAT------- 155

Human   483 IQHQKSHKNEKRFKCDQCDYACR--QERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRY 545
                          ....|.:|.  .:|.:|..|||..    |.|..|.....:..:|:.|....
 Worm   156 --------------NSSMDSSCSSDSDRCIISEKRTVF----YRCQLCSFEDERVSVLNSHVSHL 202

Human   546 HDPNFVPAAFVCSKCGKTFTRRNTMARHADN-CAGPDGVEGENGGETKKSKRGRKRKMRSKKEDS 609
            |  |..|.  || :||..|........|::. |:..|.:........|.|.....|     .|.|
 Worm   203 H--NTSPC--VC-RCGAKFEDVQGALAHSNGPCSHVDMIYNVMPTYEKASPLSPCR-----SESS 257

Human   610 SDSE-NAEPDLDDNEDEEEPAVEIEPEPEPQ------------PVTPA 644
            |||. ..:|       |||.::.....|.||            ||||:
 Worm   258 SDSGIQTDP-------EEEASIITSSLPTPQLGSSPLLLSPTLPVTPS 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_006556.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..211
		zf-H2C2_5	266..289	CDD:404746
		C2H2 Zn finger	268..288	CDD:275368
		zf-H2C2_2	280..305	CDD:463886
		C2H2 Zn finger	296..316	CDD:275368
		zf-H2C2_2	309..333	CDD:463886
		C2H2 Zn finger	324..347	CDD:275368
		zf-H2C2_5	351..375	CDD:404746	10/21 (48%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
		COG5048	<366..500	CDD:227381	24/133 (18%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		C2H2 Zn finger	409..426	CDD:275368	0/16 (0%)
		C2H2 Zn finger	439..457	CDD:275368	1/17 (6%)
		C2H2 Zn finger	469..489	CDD:275368	2/19 (11%)
		C2H2 Zn finger	497..517	CDD:275368	6/21 (29%)
		zf-H2C2_2	509..534	CDD:463886	7/24 (29%)
		C2H2 Zn finger	525..546	CDD:275368	4/20 (20%)
		C2H2 Zn finger	557..573	CDD:275368	4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..677		22/86 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	689..717
ztf-2	NP_001379129.1	C2H2 Zn finger	89..109	CDD:275370	9/19 (47%)
		zf-H2C2_2	101..125	CDD:463886	12/23 (52%)
		zf-H2C2_5	115..139	CDD:404746	12/73 (16%)
		C2H2 Zn finger	117..138	CDD:275370	10/56 (18%)