Protein Alignment CTCF and ctcf

DIOPT Version :10

• Sequence 1: NP_006556.1
• Gene: CTCF / 10664
• HGNCID: 13723
• Length: 727
• Species: Homo sapiens
• Sequence 2: NP_001116268.1
• Gene: ctcf / 100101689
• XenbaseID: XB-GENE-862914
• Length: 734
• Species: Xenopus tropicalis
• Alignment Length: 739
• Identity: 635/739 - (85%)
• Similarity: 669/739 - (90%)
• Gaps: 17/739 - (2%)

Human     1 MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQMVMMEQ 65
            ||.:..||:||:||||:|.||.||||||||||.:||.|.:.|:|||..||..||||:||||||||
 Frog     1 MESEMAEAVVEDSETFMKRKETKTYQRRREGGVDEDNCVIVQSQTDISEVPHDVNSNVQMVMMEQ 65

Human    66 LDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTS 130
            |||||||||||||||.|:.|.:..||||||||||||||||||||:|||||||  |||.||:||||
 Frog    66 LDPTLLQMKTEVMEGVVSQEGDPTVDDTQIITLQVVNMEEQPINLGELQLVQ--VPVAVPMATTS 128

Human   131 VEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDP 195
            |.||..|:|||||||||.|.||||||||||||||||||||||||||||||.||..||:|.|||||
 Frog   129 VGELHAAFENEVSKEGLQEGEPMICHTLPLPEGFQVVKVGANGEVETLEQAELQQQEEPGWQKDP 193

Human   196 DYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKK 260
            ||.||.|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
 Frog   194 DYVPPIKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSDVNAEKVVGNMKPPKPTKIKKK 258

Human   261 GVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   259 GVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP 323

Human   326 DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   324 DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRD 388

Human   391 TYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVH 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   389 TYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVH 453

Human   456 LRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGE 520
            ||||||||||||||||||.||||||||||||||||||||||||||:|||||||||||||||||||
 Frog   454 LRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEKRFKCDQCEYACRQERHMIMHKRTHTGE 518

Human   521 KPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEG 585
            ||||||||||||||||||||||||||||:|||||||||||||||||||||:||||||.||||.:|
 Frog   519 KPYACSHCDKTFRQKQLLDMHFKRYHDPSFVPAAFVCSKCGKTFTRRNTMSRHADNCTGPDGTDG 583

Human   586 ENGGET----KKSKRGRKRKMRSKKEDSSDSE-NAEPDLDDN-----EDEEEPAVEIEPEPEP-Q 639
            |||||:    ||.|||||||||||||.||||| ||||:|:|:     :||:|..||||.:||| :
 Frog   584 ENGGESEVVHKKGKRGRKRKMRSKKEGSSDSEDNAEPELEDDDDEDEDDEDETPVEIEADPEPEE 648

Human   640 PVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEA 704
            |:||.|||||||||||||:.||.|||  .|:|||:|.:..|||||||:||||.|.| |||..|.|
 Frog   649 PLTPLPPPAKKRRGRPPGKANQAKQN--AAVIQVDDHSNRAIENIIVQVKKESDLE-AEGGVEAA 710

Human   705 QPA-ATDAPNGDLTPEMILSMMDR 727
            .|. |.:|||||||||||||||||
 Frog   711 VPTPAVEAPNGDLTPEMILSMMDR 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_006556.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..211		23/30 (77%)
		zf-H2C2_5	266..289	CDD:404746	22/22 (100%)
		C2H2 Zn finger	268..288	CDD:275368	19/19 (100%)
		zf-H2C2_2	280..305	CDD:463886	24/24 (100%)
		C2H2 Zn finger	296..316	CDD:275368	19/19 (100%)
		zf-H2C2_2	309..333	CDD:463886	23/23 (100%)
		C2H2 Zn finger	324..347	CDD:275368	22/22 (100%)
		zf-H2C2_5	351..375	CDD:404746	23/23 (100%)
		C2H2 Zn finger	353..373	CDD:275368	19/19 (100%)
		COG5048	<366..500	CDD:227381	132/133 (99%)
		C2H2 Zn finger	381..401	CDD:275368	19/19 (100%)
		C2H2 Zn finger	409..426	CDD:275368	16/16 (100%)
		C2H2 Zn finger	439..457	CDD:275368	17/17 (100%)
		C2H2 Zn finger	469..489	CDD:275368	18/19 (95%)
		C2H2 Zn finger	497..517	CDD:275368	18/19 (95%)
		zf-H2C2_2	509..534	CDD:463886	24/24 (100%)
		C2H2 Zn finger	525..546	CDD:275368	20/20 (100%)
		C2H2 Zn finger	557..573	CDD:275368	14/15 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..677		77/114 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	689..717		17/28 (61%)
ctcf	NP_001116268.1	zf-H2C2_5	264..287	CDD:404746	22/22 (100%)
		C2H2 Zn finger	266..286	CDD:275368	19/19 (100%)
		zf-H2C2_2	278..303	CDD:463886	24/24 (100%)
		C2H2 Zn finger	294..314	CDD:275368	19/19 (100%)
		zf-H2C2_2	307..331	CDD:463886	23/23 (100%)
		C2H2 Zn finger	322..345	CDD:275368	22/22 (100%)
		zf-H2C2_5	349..373	CDD:404746	23/23 (100%)
		C2H2 Zn finger	351..371	CDD:275368	19/19 (100%)
		COG5048	<364..498	CDD:227381	132/133 (99%)
		C2H2 Zn finger	379..399	CDD:275368	19/19 (100%)
		C2H2 Zn finger	407..424	CDD:275368	16/16 (100%)
		C2H2 Zn finger	437..455	CDD:275368	17/17 (100%)
		C2H2 Zn finger	467..487	CDD:275368	18/19 (95%)
		C2H2 Zn finger	495..515	CDD:275368	18/19 (95%)
		zf-H2C2_2	507..532	CDD:463886	24/24 (100%)
		C2H2 Zn finger	523..544	CDD:275368	20/20 (100%)
		C2H2 Zn finger	555..571	CDD:275368	14/15 (93%)