Protein Alignment KLF1 and cbt

DIOPT Version :9

• Sequence 1: NP_006554.1
• Gene: KLF1 / 10661
• HGNCID: 6345
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Alignment Length: 371
• Identity: 103/371 - (27%)
• Similarity: 143/371 - (38%)
• Gaps: 109/371 - (29%)

Human    19 PFP-DTQDDFLKWWRSEEAQDMG-PGPPDPTEPPLHVKSEDQPGEEEDDERGADATWDLDLLLTN 81
            |.| ||:|         ||.::. |......|.|. :.....|.::.||::.|:..  ..::..|
  Fly    56 PNPSDTED---------EAPEIAVPNKKPRLEQPA-MSMTPPPDQKLDDDQKAERV--SVIMRVN 108

Human    82 FSG-------PEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPA 139
            .||       .|...:..:|..:.|..:.:....||.....|             .:.:.|....
  Fly   109 SSGAVSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDY-------------PEANVWRNLK 160

Human   140 L---RARAPDAFVGPALAP---------APAP-------EPKALALQPVYPGPGAGSSGGYFPRT 185
            .   |.||.:..:.|...|         .|||       |.|.: |.|:|..|.|.|:....
  Fly   161 FKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIKPI-LTPIYVSPVASSASQLI--- 221

Human   186 GLSVPAASGAPYGLLSGYPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGG 250
                         |||...|.                |.|.|.|.|
  Fly   222 -------------LLSTVAAQ----------------QSPTPVPKT------------------- 238

Human   251 TAEDPGVIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEG 315
                |.:..|...::......|..|...:.|:.|.|||:|.||||||||.|.||||:|:.|.||.
  Fly   239 ----PTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWEN 299

Human   316 CGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRH 361
            |..||:|||||:||.|.|||::.|:|.:|.:.|.|||||:.|:|||
  Fly   300 CDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLF1	NP_006554.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..110		20/99 (20%)
		EKLF_TAD1	22..>42	CDD:293437	5/20 (25%)
		EKLF_TAD2	59..85	CDD:293438	7/32 (22%)
		9aaTAD. /evidence=ECO:0000269|PubMed:31375868	71..79		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..271		2/21 (10%)
		zf-C2H2	279..303	CDD:278523	15/23 (65%)
		COG5048	<281..>361	CDD:227381	48/79 (61%)
		C2H2 Zn finger	284..303	CDD:275368	14/18 (78%)
		zf-H2C2_2	295..322	CDD:290200	17/26 (65%)
		C2H2 Zn finger	311..333	CDD:275368	14/21 (67%)
		zf-H2C2_2	325..350	CDD:290200	12/24 (50%)
		C2H2 Zn finger	341..361	CDD:275368	10/19 (53%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	48/76 (63%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	14/21 (67%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		zf-C2H2	323..345	CDD:278523	11/21 (52%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910