Protein Alignment CELF2 and etr-1

DIOPT Version :9

• Sequence 1: XP_024303540.1
• Gene: CELF2 / 10659
• HGNCID: 2550
• Length: 549
• Species: Homo sapiens
• Sequence 2: NP_001368521.1
• Gene: etr-1 / 173401
• WormBaseID: WBGene00001340
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 245/600 - (40%)
• Similarity: 310/600 - (51%)
• Gaps: 121/600 - (20%)

Human    36 SQETATELAGSLPSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQI 100
            ::.|......:.||....|.::.:   ..:||.||||||||||||.|:|.:.:.|||.||:|:..
 Worm    23 AESTVINAKDTTPSTAADNDVSPS---PSEPDTDAIKMFVGQIPRQWNETDCRRLFEKYGSVFSC 84

Human   101 NVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKL 165
            |:|||:|..  .||||||||||.||.|:|||.||||||.:.|||||:||||||:|..|   :|||
 Worm    85 NILRDKSTQ--ASKGCCFVTFYHRKDAIEAQGALHNIKVIEGMHHPVQMKPADTENRN---ERKL 144

Human   166 FIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTME 230
            |||.:|||.||.::|.:|:.||.||:|.:||..||.|||||||||:.|:.|..|.|.||.|||||
 Worm   145 FIGQLSKKHNEENLREIFAKFGHIEDCSVLRDQDGKSRGCAFVTFTNRSCAVVATKEMHHSQTME 209

Human   231 GCSSPIVVKFADTQKDKEQRRLQQ-----------QLAQQMQQLNTATWGNLTGLGGLTPQYLAL 284
            |||:|:|||||||||||:.:....           ..|..:|.||.|....|.  ||...|.:|.
 Worm   210 GCSAPLVVKFADTQKDKDVKTKSMITGSGAGSPKGGAASLLQNLNPALLQQLG--GGQNYQAVAS 272

Human   285 L-----------QQATSSSN-LGAFS---------GIQQMAGMN---ALQLQNLA----TLAAAA 321
            |           ||.....| ||...         |...||..|   |:.:..:|    .||...
 Worm   273 LLSLINGQQGQQQQHQQQQNVLGILGTVFAGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQG 337

Human   322 AAAQTSATSTNANPL-----STTSSALGALTSPVAASTPNSTAGAAMNS-LT------------- 367
            .|.|..|.|.....|     .:|:.:.|:..|...|:..:|.....||: ||
 Worm   338 FAVQQGAPSQQQQGLFLAHQYSTNYSTGSPDSASNATDSSSDDNNVMNNRLTPTSKMAQYGYGPL 402

Human   368 ---------------SLGTLQGLAGATVGLNNINALAGTINIAQMLSGMAALNGGLGATGLTNGT 417
                           :.....||||...|....:.:|.::...|.:: :....||
 Worm   403 IPRHPAQLYLQQRFPATAAAYGLAGGMAGAKTTSPVAASLANHQQIA-LTPFAGG---------- 456

Human   418 AGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQK-------------EGPEGANLFIY 469
            |..:|    .:..:||||..|        .||.....|.|.             :||:|||||||
 Worm   457 AAALD----HFQAMQQYALLA--------NLQATGGVGVQATTSAAQMVGNGDVKGPDGANLFIY 509

Human   470 HLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKR 534
            ||||:|||.|::..|.|||.::||||||||.||||||||||||:|..||..||.||||||||.||
 Worm   510 HLPQDFGDSDLINTFAPFGGILSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKR 574

Human   535 LKVQLKRSKNDSKPY 549
            ||||||..:.:  ||
 Worm   575 LKVQLKVDRGN--PY 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF2	XP_024303540.1	RRM1_CELF1_2_Bruno	70..153	CDD:241075	55/82 (67%)
		RRM2_CELF1_2	162..242	CDD:241078	50/79 (63%)
		RRM3_CELF1_2	457..548	CDD:241082	63/103 (61%)
etr-1	NP_001368521.1	RRM1_CELF1_2_Bruno	54..135	CDD:410040	55/82 (67%)
		PABP-1234	57..>583	CDD:130689	233/555 (42%)
		RRM2_Bruno_like	141..221	CDD:410044	50/79 (63%)
		RRM3_CELF1-6	506..578	CDD:409797	53/71 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I5181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4783
Inparanoid	1	1.050	375	1.000	Inparanoid score	I1358
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980