Protein Alignment CELF1 and NAM8

DIOPT Version :10

• Sequence 1: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_011954.1
• Gene: NAM8 / 856486
• SGDID: S000001128
• Length: 523
• Species: Saccharomyces cerevisiae
• Alignment Length: 490
• Identity: 101/490 - (20%)
• Similarity: 164/490 - (33%)
• Gaps: 185/490 - (37%)

Human    44 KMFVGQVPRTWSEKDLRELFEQYGAVYEINV-------LRDRSQN---PPQSKGCCFVTFYTRKA 98
            ::::|.:..||.:..:|:::...|.. .|||       |.:.|::   |..::|.|||.|   .:
Yeast    55 QLYMGDLDPTWDKNTVRQIWASLGEA-NINVRMMWNNTLNNGSRSSMGPKNNQGYCFVDF---PS 115

Human    99 ALEAQNA-LHNMKVLPGM-HHPIQMKPAD---SEKNNAVEDRK------LFIGMISKKCTENDIR 152
            :..|.|| |.|..::|.. :..:::..|.   |..||::.:.|      :|:|.::...||:.:.
Yeast   116 STHAANALLKNGMLIPNFPNKKLKLNWATSSYSNSNNSLNNVKSGNNCSIFVGDLAPNVTESQLF 180

Human   153 VMF-SSFGQIEECRILRGP-DGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADT 215
            .:| :.:......:|:... .|:|:|..||.||.....|.|:..| |...:.|    ..:|
Yeast   181 ELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEM-QGVFLNG----RAIK---- 236

Human   216 QKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPM 280
                                              :||
Yeast   237 ----------------------------------VGP---------------------------- 239

Human   281 GGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGA 345
                             .|..|...||.|....|||.|:
Yeast   240 -----------------TSGQQQHVSGNNDYNRSSSSLN-------------------------- 261

Human   346 LQTLAGATAGLNVGS---LAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYN 407
                     ..||.|   ..|.:.|:.|      :|..|.....::|....:||.     |:|
Yeast   262 ---------NENVDSRFLSKGQSFLSNG------NNNMGFKRNHMSQFIYPVQQQ-----PSL-- 304

Human   408 QNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCF 472
             |..|.            |....:||..|.....:.:|...|.|||.:|..|:      .:.||.
Yeast   305 -NHFTD------------PNNTTVFIGGLSSLVTEDELRAYFQPFGTIVYVKI------PVGKCC 350

Human   473 GFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRS 507
            |||.|.:.:||:|||..|.||.|...|:::...||
Yeast   351 GFVQYVDRLSAEAAIAGMQGFPIANSRVRLSWGRS 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	22/92 (24%)
		RRM2_CELF1_2	134..214	CDD:410042	20/87 (23%)
		RRM3_CELF1_2	422..513	CDD:241082	29/86 (34%)
NAM8	NP_011954.1	RRM1_NGR1_NAM8_like	55..144	CDD:410023	22/92 (24%)
		RRM2_SECp43_like	162..241	CDD:409781	21/166 (13%)
		RRM3_NGR1_NAM8_like	312..383	CDD:409782	26/76 (34%)