DRSC/TRiP Functional Genomics Resources

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Protein Alignment CELF1 and RIM4

DIOPT Version :10

Sequence 1:NP_001317201.1 Gene:CELF1 / 10658 HGNCID:2549 Length:514 Species:Homo sapiens
Sequence 2:NP_011839.1 Gene:RIM4 / 856361 SGDID:S000001016 Length:713 Species:Saccharomyces cerevisiae


Alignment Length:500 Identity:93/500 - (18%)
Similarity:159/500 - (31%) Gaps:176/500 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    27 KMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQN--------PP 83
            |:|.||...:|..:|.              .::.::.|::|.:.:|  :.||:.|        |.
Yeast   171 KVNRTLYLKNQQSIDF--------------NEISQICEKFGGLEQI--VPDRTDNQYTRRYTYPI 219

Human    84 QSKGCCFVTFYTRKAALEA-----------------------QNALHNMKVLPGMHHP----IQM 121
            .|....||.|..|..|:.|                       .|.||..|.....:|.    |..
Yeast   220 SSANSWFVQFVYRDDAIRAYANLRTDPNWIIEWAQNINVPKNYNLLHKSKFKSSKYHQNNGIINN 284

Human   122 KPADSEKNN------------------------------------------------AVEDRKLF 138
            ..:::..||                                                .::.|.:|
Yeast   285 DGSNNNDNNNSNNNNREDSRRNGDVIEEECGHVHGSDSEEKLTSDGIYDDEDKDSEITIDKRSIF 349

Human   139 IGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEG 203
            :|.:.|:.|..::...||:.|:|::..::..|..:   .||:.:.|...|..|:::.:.|..:  
Yeast   350 VGQLDKETTREELNRRFSTHGKIQDINLIFKPTNI---FAFIKYETEEAAAAALESENHAIFL-- 409

Human   204 CSSPMVVKFADTQKDKEQKRMAQ------QLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLL 262
             :..|.|::.:......:|...:      ...|.....|..:..|  ..|| |.|..:.:|.:: 
Yeast   410 -NKTMHVQYKEVGGRHNRKFSGKNGGSNFNHHQFFSTRSGKTFTG--PELN-LAPPPINMYRKM- 469

Human   263 QQTASSGNLNTLSSLHPMGGL-------NAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSV 320
             ...|.....|:....|||.:       ||..|.:......:.|...   .|...|...|.|   
Yeast   470 -SGGSQQESETMMPYMPMGPMPMGPPPPNAASLSDFDMFPPSYSTFM---KGMMPLRRKSMP--- 527

Human   321 LTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTME 385
               ::.|||||.|.||.|                          .::|||..:|.|.:....:  
Yeast   528 ---NSWSSPSSKSVNSEN--------------------------ESVNGGDENSELPSEIPES-- 561

Human   386 ALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGAN 430
                  ||  :|.||...|.||.:        :||:........|
Yeast   562 ------SG--RYNAANSFTTYNNS--------SAGNSNNNNNNNN 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CELF1NP_001317201.1 RRM1_CELF1_2_Bruno 42..125 CDD:410040 20/117 (17%)
RRM2_CELF1_2 134..214 CDD:410042 18/79 (23%)
RRM3_CELF1_2 422..513 CDD:241082 0/8 (0%)
RIM4NP_011839.1 RRM1_RIM4_like 91..176 CDD:409887 2/4 (50%)
RRM_SF 176..242 CDD:409669 17/81 (21%)
SF-CC1 300..>378 CDD:273721 9/77 (12%)
RRM2_RIM4_like 343..420 CDD:409888 18/82 (22%)
YppG 615..>669 CDD:372950
Blue background indicates that the domain is not in the aligned region.

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