DRSC/TRiP Functional Genomics Resources

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Protein Alignment CELF1 and HRB1

DIOPT Version :10

Sequence 1:NP_001317201.1 Gene:CELF1 / 10658 HGNCID:2549 Length:514 Species:Homo sapiens
Sequence 2:NP_014394.2 Gene:HRB1 / 855728 SGDID:S000004949 Length:454 Species:Saccharomyces cerevisiae


Alignment Length:417 Identity:70/417 - (16%)
Similarity:122/417 - (29%) Gaps:145/417 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   114 GMHHPIQMKPADS---EKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSR 175
            |.:.|:..:..||   ||.|......:|:|.::...|..|:...||..|::....|:.. .|..|
Yeast   137 GDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITS-RGHHR 200

Human   176 GCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASV 240
            |...|.||.......||:....|..|                  ::|...:|             
Yeast   201 GMGTVEFTNSDDVDRAIRQYDGAFFM------------------DRKIFVRQ------------- 234

Human   241 WGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTP 305
             .|....|.:..          ::....|.|......|.:                   ..:|.|
Yeast   235 -DNPPPSNNIKE----------RKALDRGELRHNRKTHEV-------------------IVKNLP 269

Human   306 SGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGG 370
            :..|     ...|..:....|:                                    :|..:..
Yeast   270 ASVN-----WQALKDIFKECGN------------------------------------VAHADVE 293

Human   371 LGSSGLSNGTGS-TMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPE------- 427
            |...|:|.|:|: :...:...:..|::|...::    ..|:|..:|..:..:..:|.:       
Yeast   294 LDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSI----EGNVLDVKSKESVHNHSDGDDVDIPMDD 354

Human   428 ------------------GANLFIY--HLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQ---TNLS 469
                              ..|..||  :||......||..:|...|.|.:|::..|.:   |.::
Yeast   355 SPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYDLFETIGKVNNAELRYDSKGAPTGIA 419

Human   470 KCFGFVSYDNPVSAQAAIQSMNGFQIG 496
                .|.|||...|...|:.:|.:..|
Yeast   420 ----VVEYDNVDDADVCIERLNNYNYG 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CELF1NP_001317201.1 RRM1_CELF1_2_Bruno 42..125 CDD:410040 2/10 (20%)
RRM2_CELF1_2 134..214 CDD:410042 18/79 (23%)
RRM3_CELF1_2 422..513 CDD:241082 22/105 (21%)
HRB1NP_014394.2 PRK12678 <29..>85 CDD:237171
RRM1_HRB1_GBP2 160..236 CDD:410184 20/108 (19%)
RRM2_HRB1_GBP2 262..334 CDD:410185 15/135 (11%)
RRM3_HRB1_GBP2 374..452 CDD:410186 21/73 (29%)
Blue background indicates that the domain is not in the aligned region.

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