Protein Alignment CELF1 and WHI4

DIOPT Version :10

• Sequence 1: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_010057.1
• Gene: WHI4 / 851302
• SGDID: S000002383
• Length: 649
• Species: Saccharomyces cerevisiae
• Alignment Length: 549
• Identity: 105/549 - (19%)
• Similarity: 182/549 - (33%)
• Gaps: 161/549 - (29%)

Human     9 LPEMMVDHCS---LNSSPVSKKMNGTLDHPDQ-PDLDAIKMFVGQV-------------PRTWSE 56
            ||....:|.|   .||||.:.:::.:..:..| ...:.|.  .|:.             |...||
Yeast   190 LPVSFQEHVSSGTTNSSPKNYQLSSSAQNEIQNQSFNTIS--YGKTSSSPLGPSAAKPRPSLLSE 252

Human    57 KDLRELF-EQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLP---GMHH 117
            :.||..| :.:|    :..:..|.::.|          :.|.:.  :|:.|.|:...|   ||
Yeast   253 RSLRFSFNDPFG----LETISQRKESVP----------FLRNSI--SQHDLSNVTTTPVPAGM-- 299

Human   118 PIQMKPADS-------EKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSR 175
            |.|.....|       |.|.::.:....:         ||  |..||||     ..|:.|
Yeast   300 PPQKDAGKSLLLLEKDEINESIWNGDELV---------ND--VGNSSFG-----ASLQEP----- 343

Human   176 GCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASV 240
                      .|:.|.:...:.:.|   .:.|:.                 ||..|....|
Yeast   344 ----------PMSSTPVMEWNASST---ANIPLF-----------------QLSSQENHQS---- 374

Human   241 WGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTP 305
                   |.|.|.:.:: .|.:....|..|||....:|....|....|.|      ..:|:..|.
Yeast   375 -------NLLPPSHHSI-SQDVPHIQSQPNLNNSGVIHSATSLPHYHLLN------QINASTKTQ 425

Human   306 SGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGG 370
            |...:::...|.|.:...:....|.||:.|.                      .|:.....:|.|
Yeast   426 SIQQSVSNVPSNLDLNLQTENGHPQSSAPNG----------------------SSIFNNQKVNQG 468

Human   371 L-----GSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNL-LTQQSIGAAGSQKEGPEGA 429
            .     .:|.:|.....:..|...|:|...:...|...|:...:| |..:....|....:.|...
Yeast   469 FLVSEQDTSTISRQKECSSTASASAFSKNNETNVAGSTTISQADLSLLAKVPPPANPADQNPPCN 533

Human   430 NLFIYHLPQEFGDQDLLQMF--------MPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAA 486
            .|::.:||.:..:|:|.|:|        :.|.|.:::....:...:...|  ||.:::...|..|
Yeast   534 TLYVGNLPPDATEQELRQLFSNQQGFRRLSFRNKMNSHGHGNGHGHGPIC--FVEFEDVSFATRA 596

Human   487 IQSMNGFQIGMKRLK------VQLKRSKN 509
            :..:.|.|:...|..      ::|..|||
Yeast   597 LAELYGSQLPHPRPSLNNKGGIRLSFSKN 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	20/99 (20%)
		RRM2_CELF1_2	134..214	CDD:410042	13/79 (16%)
		RRM3_CELF1_2	422..513	CDD:241082	22/102 (22%)
WHI4	NP_010057.1	RRM_scw1_like	531..624	CDD:409691	18/94 (19%)