DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CELF1 and celf1

DIOPT Version :9

Sequence 1:	NP_001317201.1	Gene:	CELF1 / 10658	HGNCID:	2549	Length:	514	Species:	Homo sapiens
Sequence 2:	XP_009301602.1	Gene:	celf1 / 58137	ZFINID:	ZDB-GENE-000501-1	Length:	546	Species:	Danio rerio

Alignment Length:	530	Identity:	432/530 - (81%)
Similarity:	473/530 - (89%)	Gaps:	36/530 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    17 CSLNSSPV-------SKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINV 74
            |.|:...|       ||||||:||||||||:|:|||||||:||||||..||||||.|||||||||
Zfish    21 CELSLPAVEVPALGGSKKMNGSLDHPDQPDIDSIKMFVGQIPRTWSEDQLRELFEPYGAVYEINV 85

Human    75 LRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFI 139
            ||||||||||||||||||:||||:||||||||||||:|||||||||||||||||||||||||||:
Zfish    86 LRDRSQNPPQSKGCCFVTYYTRKSALEAQNALHNMKILPGMHHPIQMKPADSEKNNAVEDRKLFV 150

Human   140 GMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGC 204
            |||||||.|||||:|||.:|||||||||||||||||||||||||.|.|||:|||:|||:||||||
Zfish   151 GMISKKCNENDIRLMFSPYGQIEECRILRGPDGLSRGCAFVTFTARQMAQSAIKSMHQSQTMEGC 215

Human   205 SSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTASSG 269
            |||:|||||||||||||||:||||||||||::|||:||||.|||:|||||||||||||||:||||
Zfish   216 SSPIVVKFADTQKDKEQKRIAQQLQQQMQQLNAASMWGNLTGLNSLGPQYLALYLQLLQQSASSG 280

Human   270 NLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSS---------- 324
              |.|::||||.|||||  ||||||||||||.|.||:|::|||||||||||||||
Zfish   281 --NALNNLHPMSGLNAM--QNLAALAAAASATQATPTGSSALTTSSSPLSVLTSSGTPSGQPAQS 341

Human   325 ------AGSSPSSSSSNSVNPIASLGALQTL-AGATAGLNVGSLAGMAALNGGLGSSGLSNGTGS 382
                  |||||:||:|:||||:|||||||:| |||.||||:.|||.||||||||||.|||||:||
Zfish   342 AWDAYKAGSSPTSSTSSSVNPMASLGALQSLAAGAGAGLNMSSLASMAALNGGLGSGGLSNGSGS 406

Human   383 TMEALTQ-AYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKE-------GPEGANLFIYHLPQE 439
            ||||||| ||||||||||||||:||:|:||:||::.|||||||       |||||||||||||||
Zfish   407 TMEALTQAAYSGIQQYAAAALPSLYSQSLLSQQNVSAAGSQKEASLNQSVGPEGANLFIYHLPQE 471

Human   440 FGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQL 504
            ||||||||||||||||:||||||||||||||||||||||||||:|||||||||||||||||||||
Zfish   472 FGDQDLLQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSSQAAIQSMNGFQIGMKRLKVQL 536

Human   505 KRSKNDSKPY 514
            ||||||||||
Zfish   537 KRSKNDSKPY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	74/82 (90%)
		RRM2_CELF1_2	134..214	CDD:410042	68/79 (86%)
		RRM3_CELF1_2	422..513	CDD:241082	88/97 (91%)
celf1	XP_009301602.1	RRM1_CELF1_2_Bruno	53..136	CDD:241075	74/82 (90%)
		ELAV_HUD_SF	56..541	CDD:273741	405/488 (83%)
		RRM2_CELF1_2	145..225	CDD:241078	68/79 (86%)
		RRM3_CELF1_2	454..545	CDD:241082	85/90 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343983
Domainoid	1	1.000	341	1.000	Domainoid score	I6111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	835	1.000	Inparanoid score	I3245
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		oto42483
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440