Protein Alignment CELF1 and bru1

DIOPT Version :9

• Sequence 1: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001260403.1
• Gene: bru1 / 34648
• FlyBaseID: FBgn0000114
• Length: 810
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 256/562 - (45%)
• Similarity: 321/562 - (57%)
• Gaps: 136/562 - (24%)

Human    17 CSLNSSPVSK---------KMNGTLDHPD-QPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYE 71
            ||.|.:.|:.         ..:.|:.:.: :||.|.|||||||||::..|..|||:||:||||:.
  Fly   321 CSANRNVVAMVDDDACFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHS 385

Human    72 INVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRK 136
            ||||||::..  .||||||||||||.|||:||:||||:|.|.||:|||||||||||..|   :||
  Fly   386 INVLRDKATG--ISKGCCFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENRN---ERK 445

Human   137 LFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIK-AMHQAQT 200
            ||:||::||..|||:|.:|...|.||||.:||..:|.|:|||||||.|:..|.:||| .:.|.:.
  Fly   446 LFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKI 510

Human   201 MEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLA-------------------- 245
            ||||:||:|||||||||:||||:: ||:|        |::| |||
  Fly   511 MEGCTSPLVVKFADTQKEKEQKKI-QQIQ--------ANLW-NLASNINIPLGQTATSVTTPILP 565

Human   246 ----------GLNTLGP---------QYLALYLQLLQQ-----TASSGNLNTLSSLHPMGGLNAM 286
                      |.:.:.|         |.:.|..||||.     ...|.:....|::...|.|..|
  Fly   566 NPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPM 630

Human   287 QLQNLAALA---------AAASAAQNTPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIAS 342
            .:|||||:|         |||:||..|..|:..||.:::.|       .|.|        ||:||
  Fly   631 TVQNLAAIAAMTQPSLSNAAAAAAAATSPGSAQLTNTAALL-------WSDP--------NPMAS 680

Human   343 LGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYN 407
             ..:.|.||..   ..||            :|.||          |...:.:...||||
  Fly   681 -AYMSTAAGLP---QFGS------------ASALS----------TSPLASVALSAAAA------ 713

Human   408 QNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCF 472
                     .|||.|.|||||.|||||||||||.|.||...|:|||||:||||||||||:|||||
  Fly   714 ---------AAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCF 769

Human   473 GFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY 514
            ||||:|||.|||.||::|||||:|.||||||||:.| |||||
  Fly   770 GFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPK-DSKPY 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	57/82 (70%)
		RRM2_CELF1_2	134..214	CDD:410042	45/80 (56%)
		RRM3_CELF1_2	422..513	CDD:241082	70/90 (78%)
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	57/82 (70%)
		ELAV_HUD_SF	359..808	CDD:273741	242/520 (47%)
		RRM2_Bruno_like	443..524	CDD:241080	45/80 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	61/77 (79%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146318
Domainoid	1	1.000	97	1.000	Domainoid score	I7253
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1906
Isobase	1	0.950	-	0	Normalized mean entropy	S2786
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm41419
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740