Protein Alignment CELF1 and etr-1

DIOPT Version :9

• Sequence 1: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001368521.1
• Gene: etr-1 / 173401
• WormBaseID: WBGene00001340
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 249/579 - (43%)
• Similarity: 315/579 - (54%)
• Gaps: 107/579 - (18%)

Human    20 NSSPVSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQ 84
            :::|.:...|.....|.:||.|||||||||:||.|:|.|.|.|||:||:|:..|:|||:|..  .
 Worm    32 DTTPSTAADNDVSPSPSEPDTDAIKMFVGQIPRQWNETDCRRLFEKYGSVFSCNILRDKSTQ--A 94

Human    85 SKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTEN 149
            ||||||||||.||.|:|||.||||:||:.|||||:||||||:|..|   :||||||.:|||..|.
 Worm    95 SKGCCFVTFYHRKDAIEAQGALHNIKVIEGMHHPVQMKPADTENRN---ERKLFIGQLSKKHNEE 156

Human   150 DIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFAD 214
            ::|.:|:.||.||:|.:||..||.||||||||||.|:.|..|.|.||.:|||||||:|:||||||
 Worm   157 NLREIFAKFGHIEDCSVLRDQDGKSRGCAFVTFTNRSCAVVATKEMHHSQTMEGCSAPLVVKFAD 221

Human   215 TQKDKE--QKRMAQQLQQQMQQISAASVWGNL--AGLNTLGP----QYLALYLQLL--------- 262
            |||||:  .|.|.........:..|||:..||  |.|..||.    |.:|..|.|:
 Worm   222 TQKDKDVKTKSMITGSGAGSPKGGAASLLQNLNPALLQQLGGGQNYQAVASLLSLINGQQGQQQQ 286

Human   263 --QQTASSGNLNTLSSLHPMGGLNAMQLQN------LAALA--------AAASAAQNTPS----- 306
              ||....|.|.|:.:.:|:.|..||..||      :|.:|        ...:..|..||
 Worm   287 HQQQQNVLGILGTVFAGNPLLGNPAMAAQNQFDAITMAQIAHQQQMLALQGFAVQQGAPSQQQQG 351

Human   307 -------GTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASL--------------------- 343
                   .||..|.|....|..|.|: |..::..:|.:.|.:.:
 Worm   352 LFLAHQYSTNYSTGSPDSASNATDSS-SDDNNVMNNRLTPTSKMAQYGYGPLIPRHPAQLYLQQR 415

Human   344 ----GALQTLAGATAGLNVGS-LAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALP 403
                .|...|||..||....| :|...|.:..:..:..:.|.     |....:..:||||..|
 Worm   416 FPATAAAYGLAGGMAGAKTTSPVAASLANHQQIALTPFAGGA-----AALDHFQAMQQYALLA-- 473

Human   404 TLYNQNLLTQQSIGAAGSQK-------------EGPEGANLFIYHLPQEFGDQDLLQMFMPFGNV 455
                 ||   |:.|..|.|.             :||:|||||||||||:|||.||:..|.|||.:
 Worm   474 -----NL---QATGGVGVQATTSAAQMVGNGDVKGPDGANLFIYHLPQDFGDSDLINTFAPFGGI 530

Human   456 VSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY 514
            :||||||||.||||||||||||:|..||..||.:|||||||.||||||||..:.:  ||
 Worm   531 LSAKVFIDKVTNLSKCFGFVSYENAQSATNAISAMNGFQIGSKRLKVQLKVDRGN--PY 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	56/82 (68%)
		RRM2_CELF1_2	134..214	CDD:410042	49/79 (62%)
		RRM3_CELF1_2	422..513	CDD:241082	63/103 (61%)
etr-1	NP_001368521.1	RRM1_CELF1_2_Bruno	54..135	CDD:410040	56/82 (68%)
		PABP-1234	57..>583	CDD:130689	238/546 (44%)
		RRM2_Bruno_like	141..221	CDD:410044	49/79 (62%)
		RRM3_CELF1-6	506..578	CDD:409797	53/71 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I5181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I1358
Isobase	1	0.950	-	0	Normalized mean entropy	S2786
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		oto22385
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930