DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KHDRBS3 and qkr58E-3

DIOPT Version :9

Sequence 1:	NP_006549.1	Gene:	KHDRBS3 / 10656	HGNCID:	18117	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_001246460.1	Gene:	qkr58E-3 / 37559	FlyBaseID:	FBgn0022984	Length:	317	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	98/270 - (36%)
Similarity:	144/270 - (53%)	Gaps:	28/270 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     3 EKYLPELMAEKDSLDPSFTHALRLVNQEIEK-FQKGEGKDEEKYIDVVINKNMKLGQKVLIPVKQ 66
            :|:|.:|..|:..|...|.....|:::.::: :..|....:|.|.||...|.||:.|||.:||||
  Fly    26 QKFLADLDEERQRLSADFPLCALLIDEAVDRVYCTGRIPGKEFYADVYKQKPMKITQKVFVPVKQ 90

Human    67 FPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLI 131
            :|||||.||:|||:||||:||||||..|::|.|:.|:||:.|||:||.:|:.:|.||..||.:.:
  Fly    91 YPKFNFTGKILGPKGNSLRRLQEETQCKIAIKGRSSIRDRNKEEQLRSTGDPRYAHLQKDLFLEV 155

Human   132 EVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRG 196
            ...|.|||.|||:.:||.||:|:||||.|||:...||:||..::..|               .:.
  Fly   156 STVATPAECYARIAYALAEIRKYLIPDKNDEVSHEQLRELMEMDPES---------------AKN 205

Human   197 VPAPAITRGR--------GGVTARPVGV-VVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPT 252
            :..|.:...|        |.....|..: ::.|....|..|.............:.|:.   |||
  Fly   206 IHGPNLEAYRSVFDKKFGGNSNGAPKYINLIKRAAENPPEVDDVEEVAYEYEHRMPPKR---PPT 267

Human   253 GYRPPPPPPT 262
            ||....|.|:
  Fly   268 GYEYSKPRPS 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KHDRBS3	NP_006549.1	Involved in homodimerization. /evidence=ECO:0000269\|PubMed:26758068	1..160		75/157 (48%)
		Qua1	4..53	CDD:406639	12/49 (24%)
		KH-I_KHDRBS3	48..160	CDD:411898	64/111 (58%)
		Interaction with SIAH1. /evidence=ECO:0000269\|PubMed:15163637	212..251		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..267		12/51 (24%)
		Sam68-YY	266..320	CDD:406871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..346
qkr58E-3	NP_001246460.1	SF1_like-KH	81..200	CDD:239088	67/118 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4151
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	1	0.900	-	-		OOG6_110428
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.760