Protein Alignment DMRT2 and dmrt2a

DIOPT Version :10

• Sequence 1: NP_870987.2
• Gene: DMRT2 / 10655
• HGNCID: 2935
• Length: 561
• Species: Homo sapiens
• Sequence 2: NP_571027.1
• Gene: dmrt2a / 30129
• ZFINID: ZDB-GENE-990621-7
• Length: 507
• Species: Danio rerio
• Alignment Length: 573
• Identity: 293/573 - (51%)
• Similarity: 361/573 - (63%)
• Gaps: 96/573 - (16%)

Human    12 DWEIDVESLELEEDVCGAPRSTPPGPSPPPADGDCEDDEDDDGVDEDAEEE----GDGEEAGASP 72
            ::|||||.||.|.|    .::...||.           |||.|..:|.:.:    |.|::
Zfish     8 EFEIDVEGLETESD----DQAVFTGPG-----------EDDTGSKDDDKSDRLNLGSGDQ----- 52

Human    73 GMPGQPEQRGGPQPRPPLAPQASPAGTGPRERCTPAGGGAEPRKLSRTPKCARCRNHGVVSCLKG 137
                                                      |||||||||||||||||||||||
Zfish    53 ------------------------------------------RKLSRTPKCARCRNHGVVSCLKG 75

Human   138 HKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFERKAVYQRQVRAPSL 202
            ||||||||||||||||||||||||||||||||||||||||||::|||...||:.:|||.:|..::
Zfish    76 HKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGITGKQIPVERRNIYQRHIRPSTM 140

Human   203 LAKSILEGYRPIPAETYVGGTFPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQ--A 265
            |||||||||||:..:.::|....||||:||||||||||||||||.|||||||||||:||::|  :
Zfish   141 LAKSILEGYRPVQNDPFLGANPALPPPLSDRMRKRRAFADKELETIMLEREYKERELLESTQSNS 205

Human   266 AALFLPNRMVPGPDYNSYKSAYS----PSPVEPPSKDFCNFLPTCLDLTMQYSGSG----NMELI 322
            |:||:|..||...:|||||:|:|    ||.|||..||.|.|||.||||::||:.:|    |:|||
Zfish   206 ASLFMPGSMVHAAEYNSYKTAFSSASAPSTVEPSPKDLCGFLPGCLDLSLQYAATGGTTANVELI 270

Human   323 SSNVSVATTYRQYPLSSRFLVWPK-CGPISDTLLYQQCLLNATTSVQALKPGASWDLKGARVQDG 386
            ||||||||||||||||.||::||: ...|||.|||||||||| |:||.|||||.||.|.....:.
Zfish   271 SSNVSVATTYRQYPLSPRFVMWPRGSSSISDALLYQQCLLNA-TAVQNLKPGAVWDPKMMSSTES 334

Human   387 LSAEQDMMPSKLEGSLVLPHTPEIQTTRSDLQ---GHQAVPERSAFSPPRRNFSPIVDTDSLAAQ 448
            ...|||...|:||||.|.|.:.::|....:.|   ||.. ..|||||||:|.:..:....: .:.
Zfish   335 HPPEQDAPASRLEGSRVAPESSDLQPGPREAQTGLGHNG-GARSAFSPPKRTYGQVFSPQA-GSH 397

Human   449 GHVLTKISKENTRHPLPLRHNPFHSLFQQTLTDKSGPELKTPFVKEAFEETPKKHRECLVKDNQK 513
            .||:..:||:..:|.|.::.|.||||.||||.||: |:...|:.||..||..||.||...||
Zfish   398 EHVINNMSKDTAKHTLSMKLNSFHSLIQQTLNDKN-PDTNRPYCKELLEEAAKKFREGTAKD--- 458

Human   514 YTFTI-----DRCAKDLFVAKQVGTKLSVNEPLSFSVESILKRPSSAITRVSQ 561
               |:     :|.||| ||||...:|::..|.||||||:|||||:.::.|.||
Zfish   459 ---TVGLKSSERAAKD-FVAKPRCSKVTAGESLSFSVEAILKRPALSLNRKSQ 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMRT2	NP_870987.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..119		21/110 (19%)
		DM	119..165	CDD:459924	45/45 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	414..435		10/23 (43%)
dmrt2a	NP_571027.1	DM	57..103	CDD:459924	45/45 (100%)