DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPINT2 and spint2

DIOPT Version :9

Sequence 1:	NP_066925.1	Gene:	SPINT2 / 10653	HGNCID:	11247	Length:	252	Species:	Homo sapiens
Sequence 2:	NP_001039077.1	Gene:	spint2 / 733874	XenbaseID:	XB-GENE-947329	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	288	Identity:	97/288 - (33%)
Similarity:	137/288 - (47%)	Gaps:	75/288 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    33 SIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATG 97
            ::.||||...|.|.|||:..|||||....:|:.|.||||.||.||::.:|.|:.|||.||...:.
Frog   114 TLKDFCLPEAVTGPCRAAFERWWYNPNTQTCENFTYGGCKGNLNNHIGEEVCMNKCAGVTAEMSN 178

Human    98 DL--ATSRNAADSSVP-------------SAPRRQ-DSEDHSSDMFNY----------------- 129
            |:  .:.|.|..:|.|             |.||.. |:|..:...|.|
Frog   179 DILPPSKRMAEANSDPACTGKGVIGNCRASFPRWYFDAESQNCISFTYGGCGGTENNHKSVQECA 243

Human   130 ---------------------EEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSY 173
                                 .|||.|.::||||||||.|||:||...:|..|.|||||||||:|
Frog   244 DRCIVSKPEPAKVQAPMTGSFSEYCAAPSLTGPCRASFRRWYYDVTTATCVAFTYGGCRGNKNNY 308

Human   174 RSEEACMLRCFRQQEN-------------PPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVAR 225
            .|.|.|:..|..:.::             ..:.|.:.:.:|||:.::|:|       |:.:::|:
Frog   309 LSVEDCVKNCAGRLDDDHTSDQTVLHRSITAVVLPALLAILAGILLLVMI-------VFFVKMAK 366

Human   226 RNQERA-LRTVWSSGDDKEQLVKNTYVL 252
            :||..| ...:||..||||.|:.|.|.|
Frog   367 KNQRDAHFGAIWSPIDDKECLMNNAYTL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPINT2	NP_066925.1	Kunitz_BPTI	37..88	CDD:394972	25/50 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..122		9/35 (26%)
		Kunitz_BPTI	132..183	CDD:394972	31/50 (62%)
spint2	NP_001039077.1	MANEC	19..104	CDD:384556
		Kunitz_BPTI	118..169	CDD:333766	25/50 (50%)
		KU	194..247	CDD:238057	8/52 (15%)
		KU	266..318	CDD:238057	32/51 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7955
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010905
OrthoInspector	1	1.000	-	-		oto157199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3049
SonicParanoid	1	1.000	-	-		X8445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940