DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPINT2 and Y55F3BR.2

DIOPT Version :9

Sequence 1:	NP_066925.1	Gene:	SPINT2 / 10653	HGNCID:	11247	Length:	252	Species:	Homo sapiens
Sequence 2:	NP_001294458.1	Gene:	Y55F3BR.2 / 190314	WormBaseID:	WBGene00021939	Length:	1549	Species:	Caenorhabditis elegans

Alignment Length:	165	Identity:	47/165 - (28%)
Similarity:	74/165 - (44%)	Gaps:	19/165 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    53 RWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATV-----TENATGDLATSRNAADSSVPS 112
            |::||.|||.|..|.:.|..||.||:..:.:|...||.:     :....|:.:..|.|.|:..||
Worm   461 RYYYNPTDGQCHPFTFNGFLGNFNNFQNQADCQLFCARLQCPHGSPLTNGNGSPQRCARDTDCPS 525

Human   113 APRRQDSEDHSSDMFNY------EEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKN 171
            .        |:..|.:.      :..||.....|.|:.|..:::::.|..:|.:|:|.||:||.|
Worm   526 T--------HTCAMEHQVCCPTPQTLCTEPLRVGDCKQSVRQFWYNAETKTCESFLYTGCQGNNN 582

Human   172 SYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFV 206
            .:.|...|...|......|..|.|...|..:|.|:
Worm   583 RFNSLNECQSYCKNINAEPKCPQGRAYVDFSGKFM 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPINT2	NP_066925.1	Kunitz_BPTI	37..88	CDD:394972	14/34 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..122		5/21 (24%)
		Kunitz_BPTI	132..183	CDD:394972	16/50 (32%)
Y55F3BR.2	NP_001294458.1	EB	137..183	CDD:279949
		KU	<324..365	CDD:197529
		KU	<459..496	CDD:197529	14/34 (41%)
		Kunitz_BPTI	544..595	CDD:278443	16/50 (32%)
		KU	649..703	CDD:197529
		KU	756..813	CDD:294074
		EB	1190..1241	CDD:279949
		EB	1246..1297	CDD:279949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161450445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840