DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPINT2 and T22F7.3

DIOPT Version :9

Sequence 1:	NP_066925.1	Gene:	SPINT2 / 10653	HGNCID:	11247	Length:	252	Species:	Homo sapiens
Sequence 2:	NP_497207.4	Gene:	T22F7.3 / 188757	WormBaseID:	WBGene00020702	Length:	1517	Species:	Caenorhabditis elegans

Alignment Length:	168	Identity:	47/168 - (27%)
Similarity:	72/168 - (42%)	Gaps:	30/168 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    38 CLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATV---TENATGDL 99
            |...|.:|.|.:::.|:|||....||::|.|.||.||.||:.|...|.:||..:   .:...|..
Worm   533 CTQPKRLGDCTSAVRRYWYNAATRSCEMFQYTGCQGNDNNFNTLMACQQKCRGIHVEPKCQHGRA 597

Human   100 ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPC--RASFP--------------- 147
            ...||.      :..:..|.::......||  .|:.:..|..|  ..:|.
Worm   598 FRDRNG------NFQQCSDKQNGPKCPVNY--VCSFDGTTHGCCPTKAFTCSLNPDKGVQCGSGR 654

Human   148 --RWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRC 183
              |:||:..:.||.:|.|.||.||.|::.:.|.|...|
Worm   655 SYRYYFNSNKQSCESFQYEGCDGNANNFLTSEDCQHYC 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPINT2	NP_066925.1	Kunitz_BPTI	37..88	CDD:394972	20/49 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..122		3/21 (14%)
		Kunitz_BPTI	132..183	CDD:394972	18/69 (26%)
T22F7.3	NP_497207.4	EB	144..199	CDD:396311
		KU	311..365	CDD:197529
		KU	<450..486	CDD:197529
		Kunitz_BPTI	533..584	CDD:394972	21/50 (42%)
		Kunitz_BPTI	639..693	CDD:394972	15/54 (28%)
		Kunitz_BPTI	747..800	CDD:394972
		Lustrin_cystein	1077..1118	CDD:405330
		EB	1218..1269	CDD:396311
		EB	1295..1346	CDD:396311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810