Protein Alignment IGF2BP2 and PBP2

DIOPT Version :10

• Sequence 1: NP_001278798.1
• Gene: IGF2BP2 / 10644
• HGNCID: 28867
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_009792.3
• Gene: PBP2 / 852533
• SGDID: S000000437
• Length: 413
• Species: Saccharomyces cerevisiae
• Alignment Length: 393
• Identity: 103/393 - (26%)
• Similarity: 159/393 - (40%)
• Gaps: 84/393 - (21%)

Human   158 ISYIPDEEVSSPSPPQRAQRGDHSSREQ--------------GHAPGGTSQARQI--DFPLRILV 206
            |:..|...:.||:..:| ::|:.:|.||              .|:.........:  |..||:|.
Yeast    10 ITTTPTTVLVSPNTLKR-KKGEDTSEEQLEAEIKRVALKDADSHSDNDHDSPDNVPSDVHLRMLC 73

Human   207 PTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKE 271
            ..:....|:|.:|.||..|..:|.:|::|..... |..|:.|.:..|.:..::|..||:..:.:|
Yeast    74 LVKHASLIVGHKGATISRIKSETSARINISNNIR-GVPERIVYVRGTCDDVAKAYGMIVRALLEE 137

Human   272 ADETKLAE--EIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVK 334
            .......|  ||.:.:|..:.|:|.:|||.|..|::||..:..|: .:|...|.:.| :|.:|:.
Yeast   138 HGNEDNGEDIEISINLLIPHHLMGCIIGKRGSRLREIEDLSAAKL-FASPNQLLLSN-DRILTIN 200

Human   335 GTVEACASAEIEIMKKL-------------REAFE-----NDMLAVNQQANLI------------ 369
            |..:|...|...|.:.|             |..:.     |.:|..:.|.|.|
Yeast   201 GVPDAIHIATFYISQTLLNFQMESPQKNVKRSIYYQPTQFNSVLIDHSQPNTIFHQRNHQYHPSD 265

Human   370 ------PGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHP------FTTHSGYFSSLYPHHQFG 422
                  |..||.   |.||.||:.:|.........|..:.|      .|...|...|
Yeast   266 KLLSYKPNKNLP---ISSTLLSMATPQYTTASVANATAFQPNFVIPNVTVLDGPVIS-------- 319

Human   423 PFPHHH---SYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIA-PAEGPDVSERMVI 483
            |.|.:|   ::.:|||   ||..:.||.:|||.|.||..:....|.||.|. |.||.  |||.:.
Yeast   320 PAPGNHLLMNFVQQEI---FIDEKFVGNVIGKDGKHINSVKESTGCSIIIQDPVEGS--SERRLT 379

Human   484 ITG 486
            |.|
Yeast   380 IRG 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070
		RRM2_IGF2BP2	82..163	CDD:410038	1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..194		8/44 (18%)
		KH-I_IGF2BP2_rpt1	201..274	CDD:411919	20/72 (28%)
		KH-I_IGF2BP2_rpt2	282..358	CDD:411922	22/93 (24%)
		KH-I_IGF2BP2_rpt3	432..508	CDD:411925	25/56 (45%)
		KH-I_IGF2BP2_rpt4	515..592	CDD:411928
PBP2	NP_009792.3	KH-I_PCBP_rpt1	69..137	CDD:411866	19/68 (28%)
		KH-I_Rnc1_rpt2	150..218	CDD:411884	20/69 (29%)
		KH-I	334..394	CDD:411802	24/54 (44%)