DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IGF2BP2 and ps

DIOPT Version :10

Sequence 1:NP_001278798.1 Gene:IGF2BP2 / 10644 HGNCID:28867 Length:605 Species:Homo sapiens
Sequence 2:NP_001262415.1 Gene:ps / 44258 FlyBaseID:FBgn0261552 Length:780 Species:Drosophila melanogaster


Alignment Length:646 Identity:135/646 - (20%)
Similarity:213/646 - (32%) Gaps:233/646 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    73 YSVSKKLRSRKIQIRNIPPHLQWEVLD-GLLAQYGTVENVEQVFAFSLVNTDTETAVVNVTYATR 136
            ||::.....::|:....|.|:....:| ..|::.|:......      ..|.|.||..|...|..
  Fly   140 YSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPG------AQTPTATASGNTAAALA 198

Human   137 EEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDH--------------------S 181
            ..|..|....||   .|.|...:...:...||.:..|:.|.|::                    .
  Fly   199 SAAAAAAAATSG---GNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIE 260

Human   182 SREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKEN--SGAA 244
            :....|...|     :..:.::||||....||||||.|.||.::.|.|.:||.:.:..:  .|..
  Fly   261 NNNNNHIHHG-----ETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTT 320

Human   245 EKPVTIHATPEGTSEACRMILE-IMQKEADETKLAEEI-------------PLKILAHNGLVGRL 295
            |:...|    .|::||..:::| ||.|..::..|..:|             .:|||..|...|.:
  Fly   321 ERVCLI----TGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMI 381

Human   296 IGKEGRNLKKIEHETGTKITISSL-QDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFEN-- 357
            |||.|..:|:|:.|:|:.:.||.. .|:|:  .||.||:.|..|...:|...|:.|:.|..::  
  Fly   382 IGKGGAFIKQIKEESGSYVQISQKPTDVSL--QERCITIIGDKENNKNACKMILSKIVEDPQSGT 444

Human   358 --------------------DMLAVNQQA-------------NLIPGLNLSA-LGIFSTGLSVLS 388
                                ...|.||.|             ..|.|.|.:| |.:..||:::..
  Fly   445 CLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSI 509

Human   389 PPAGPRGAPPAAPYHPFTTH-------SGYFSSL----------------------YPH----H- 419
            ....|..||..|.......|       |||..::                      ..|    | 
  Fly   510 NLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHS 574

Human   420 --------------------------------------------------------------QFG 422
                                                                          ||.
  Fly   575 TLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQFD 639

Human   423 PFPH---------------HHSY--------------------------PEQEIVNLFIPTQAVG 446
            ||.|               ::|:                          ..::..|:.:|...:|
  Fly   640 PFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVIIG 704

Human   447 AIIGKKGAHIKQLARFAGASIKIAPAE--GPDVSERMVIITGPPEAQFKAQGRIFGKLKEE 505
            ||:|..|..:.::...:||:::|:...  .|....|:|.|||.|.|..|||..|..|:.||
  Fly   705 AILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINEE 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGF2BP2NP_001278798.1 RRM1_IGF2BP2 2..78 CDD:241070 2/4 (50%)
RRM2_IGF2BP2 82..163 CDD:410038 18/81 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..194 7/50 (14%)
KH-I_IGF2BP2_rpt1 201..274 CDD:411919 27/75 (36%)
KH-I_IGF2BP2_rpt2 282..358 CDD:411922 27/98 (28%)
KH-I_IGF2BP2_rpt3 432..508 CDD:411925 25/76 (33%)
KH-I_IGF2BP2_rpt4 515..592 CDD:411928
psNP_001262415.1 KH-I_NOVA_rpt1 274..345 CDD:411863 27/74 (36%)
KH-I_NOVA_rpt2 367..436 CDD:411864 25/70 (36%)
KH-I_NOVA_rpt3 694..762 CDD:411807 22/67 (33%)
Blue background indicates that the domain is not in the aligned region.

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