back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGF2BP2 and Psi

DIOPT Version :10

Sequence 1:	NP_001278798.1	Gene:	IGF2BP2 / 10644	HGNCID:	28867	Length:	605	Species:	Homo sapiens
Sequence 2:	NP_995862.1	Gene:	Psi / 36889	FlyBaseID:	FBgn0014870	Length:	797	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	106/512 - (20%)
Similarity:	174/512 - (33%)	Gaps:	162/512 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   162 PDEEVSSPSPPQRAQRGDHSSRE-----QGHAPGGTS------QARQIDFPL----------RIL 205
            |:.:.|..||.......:.||..     .|..|||.|      ||..:...|          :|.
  Fly    63 PESKRSLGSPEYANNSSNMSSGSGGGGGGGGGPGGASITQAIAQAAAVAARLAASAGTSCEEQIR 127

Human   206 VPTQFVGAIIGKEGL-TIKNI---------TKQTQSRV------------------DIHRKENSG 242
            :|....||.:|:... ||.:|         ..|.|.||                  ::..:...|
  Fly   128 LPESVAGAFMGRSSNDTITHIQAESGVKVQVMQDQDRVIMLRGQRDTVTKGREMIQNMANRAGGG 192

Human   243 AAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIE 307
            ..|..:||:..|.|.| ......|||            ||      ...||.:|||.|..:|:::
  Fly   193 QVEVLLTINMPPPGPS-GYPPYQEIM------------IP------GAKVGLVIGKGGDTIKQLQ 238

Human   308 HETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGL 372
            .:||.|:.|  :||    .|.:                |::|.||.:.|...:...:|..|....
  Fly   239 EKTGAKMII--IQD----GPNQ----------------ELIKPLRISGEAQKIEHAKQMVLDLIA 281

Human   373 NLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVN 437
            ...|.|....|..     .|..|..|...::.|...:|                      .|...
  Fly   282 QKDAQGQQQGGRG-----GGGGGGGPGMGFNNFNNGNG----------------------GESTE 319

Human   438 LFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKL 502
            :|:|..|||.:|||.|..|:::....|..::....:..::.:|..:|.|..:....|:..|.|.:
  Fly   320 VFVPKIAVGVVIGKGGDMIRKIQTECGCKLQFIQGKNDEMGDRRCVIQGTRQQVDDAKRTIDGLI 384

Human   503 K---EENFFN------------------------------PKEEVKLEAHIRVPSSTAGRVIGKG 534
            :   :.|..|                              .:||:.    ..||:|..|.|||:|
  Fly   385 ENVMQRNGMNRNGNGGGGGPGGDSGNSNYGYGYGVNHAQGGREEIT----FLVPASKCGIVIGRG 445

Human   535 GKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQ 591
            |:|:..:...:.|...:.|:.:...||::        |.|:....::....|.:.::
  Fly   446 GETIKLINQQSGAHTEMDRNASNPPNEKL--------FKSKGTTDQVEAARQMISEK 494

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.