Protein Alignment IGF2BP2 and Imp

DIOPT Version :10

• Sequence 1: NP_001278798.1
• Gene: IGF2BP2 / 10644
• HGNCID: 28867
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 220/567 - (38%)
• Similarity: 320/567 - (56%)
• Gaps: 78/567 - (13%)

Human    76 SKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVFAFSLVNTDTETAVVNVTYATREEAK 140
            :..:.:.||.|..||...::|.::.||..||.|:..|     ::.:.|..|..|::|:...|:|:
  Fly    36 TSSVTTSKILISGIPMQTRFEDIEPLLKPYGIVKQCE-----AISSKDQNTQTVHITFENPEQAQ 95

Human   141 IAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRIL 205
            .|...|:|.:||........:...:..|    ||.||..:        ||.....||.|||||||
  Fly    96 RAAVGLNGVEFEGSKLHAEQLDKNQRRS----QRNQRNPY--------PGMPGPGRQADFPLRIL 148

Human   206 VPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQK 270
            |.::.||||||::|.||:.||:|:::|||:|||||.|:.||.:||:..||..:.||:.|||:||:
  Fly   149 VQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQ 213

Human   271 EADETKLAE------EIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPER 329
            ||..|...|      ||.|||||||.|:||:|||.|..:|:|..:|.||||:||:.|::.:|.||
  Fly   214 EAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLER 278

Human   330 TITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLN----LSALG---IFSTGLSVL 387
            .|||||.:|..:.||.:|..|||:::|||:.|:..|:.:.|||:    :|..|   :|:|.:
  Fly   279 IITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFNTSM--- 340

Human   388 SPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGP-FPHHHSYPEQEIVNLFIPTQAVGAIIGK 451
                            ||.:...:..|..|.....| ||:    ..||...|:||..|||||||.
  Fly   341 ----------------PFPSCQSFAMSKTPASVVPPVFPN----DLQETTYLYIPNNAVGAIIGT 385

Human   452 KGAHIKQLARFAGASIKIAP--AEGP--DVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKE 512
            :|:||:.:.||:.||:||||  |:.|  ..:||.|.|.|.||.|:|||..||.|::||.|....:
  Fly   386 RGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTD 450

Human   513 EVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQ-TPDE--NEEVIVRIIGHFFAS 574
            :|:|...:.|.||..||:|||||:.|.|||.:|.:.:.:|... .|..  :||..|.|||.|::.
  Fly   451 DVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSV 515

Human   575 QTAQRKIREIV----------------QQVKQQEQKYPQGVASQRSK 605
            |:|||:||.::                :|::||:|.. .|.||..|:
  Fly   516 QSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSL-AGAASSGSQ 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070	0/1 (0%)
		RRM2_IGF2BP2	82..163	CDD:410038	23/80 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..194		7/30 (23%)
		KH-I_IGF2BP2_rpt1	201..274	CDD:411919	42/72 (58%)
		KH-I_IGF2BP2_rpt2	282..358	CDD:411922	40/75 (53%)
		KH-I_IGF2BP2_rpt3	432..508	CDD:411925	41/79 (52%)
		KH-I_IGF2BP2_rpt4	515..592	CDD:411928	33/95 (35%)
Imp	NP_001245616.1	RRM2_VICKZ	42..118	CDD:409794	23/80 (29%)
		KH-I_IGF2BP_rpt1	144..211	CDD:411828	38/66 (58%)
		KH-I_IGF2BP_rpt2	231..302	CDD:411829	38/70 (54%)
		KH-I_IGF2BP_rpt3	368..437	CDD:411830	35/68 (51%)
		KH-I_IGF2BP_rpt4	455..523	CDD:411831	28/67 (42%)