Protein Alignment IGF2BP2 and Igf2bp2

DIOPT Version :10

• Sequence 1: NP_001278798.1
• Gene: IGF2BP2 / 10644
• HGNCID: 28867
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_898850.2
• Gene: Igf2bp2 / 319765
• MGIID: 1890358
• Length: 592
• Species: Mus musculus
• Alignment Length: 605
• Identity: 567/605 - (93%)
• Similarity: 580/605 - (95%)
• Gaps: 13/605 - (2%)

Human     1 MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELH 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELH 65

Human    66 GKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVFAFSLVNTDTETAVVN 130
            |||||||||||||||||:||||||||||||||||||||:|||||||||      |||||||||||
Mouse    66 GKIMEVDYSVSKKLRSRRIQIRNIPPHLQWEVLDGLLAEYGTVENVEQ------VNTDTETAVVN 124

Human   131 VTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQA 195
            |||.||||||:|:|||||||||:|||||||||||||||||||.||       |||||.||.:|||
Mouse   125 VTYMTREEAKLAIEKLSGHQFEDYSFKISYIPDEEVSSPSPPHRA-------REQGHGPGSSSQA 182

Human   196 RQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   183 RQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEA 247

Human   261 CRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIY 325
            ||||||||||||||||||||:|||||||||.||||||||||||||||||||||||||||||||||
Mouse   248 CRMILEIMQKEADETKLAEEVPLKILAHNGFVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIY 312

Human   326 NPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPP 390
            ||||||||:||:||||:|||||||||||||||||||||||||||||||||||||||||||||.||
Mouse   313 NPERTITVRGTIEACANAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLPPP 377

Human   391 AGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH 455
            |||||.||:.|||||.|||||||||||||.||||||||||||||.|:||||||||||||||||||
Mouse   378 AGPRGVPPSPPYHPFATHSGYFSSLYPHHHFGPFPHHHSYPEQETVSLFIPTQAVGAIIGKKGAH 442

Human   456 IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHI 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   443 IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHI 507

Human   521 RVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIV 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   508 RVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIV 572

Human   586 QQVKQQEQKYPQGVASQRSK 605
            ||||||||:||||||.||||
Mouse   573 QQVKQQEQRYPQGVAPQRSK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070	75/75 (100%)
		RRM2_IGF2BP2	82..163	CDD:410038	68/80 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..194		19/30 (63%)
		KH-I_IGF2BP2_rpt1	201..274	CDD:411919	72/72 (100%)
		KH-I_IGF2BP2_rpt2	282..358	CDD:411922	71/75 (95%)
		KH-I_IGF2BP2_rpt3	432..508	CDD:411925	73/75 (97%)
		KH-I_IGF2BP2_rpt4	515..592	CDD:411928	76/76 (100%)
Igf2bp2	NP_898850.2	RRM1_IGF2BP2	2..78	CDD:241070	75/75 (100%)
		RRM2_IGF2BP2	82..157	CDD:410038	68/80 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..182		20/31 (65%)
		KH-I_IGF2BP2_rpt1	188..261	CDD:411919	72/72 (100%)
		KH-I	265..360	CDD:469614	89/94 (95%)
		KH-I_IGF2BP2_rpt3	419..495	CDD:411925	73/75 (97%)
		KH-I_IGF2BP2_rpt4	502..579	CDD:411928	76/76 (100%)