Protein Alignment IGF2BP2 and Igf2bp2

DIOPT Version :10

• Sequence 1: NP_001278798.1
• Gene: IGF2BP2 / 10644
• HGNCID: 28867
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_001257527.1
• Gene: Igf2bp2 / 303824
• RGDID: 1305614
• Length: 592
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 569/605 - (94%)
• Similarity: 580/605 - (95%)
• Gaps: 13/605 - (2%)

Human     1 MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELH 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELH 65

Human    66 GKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVFAFSLVNTDTETAVVN 130
            ||||||||||||||||||||||||||||||||||||||:|||||||||      |||||||||||
  Rat    66 GKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAEYGTVENVEQ------VNTDTETAVVN 124

Human   131 VTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQA 195
            |||.||||||:|:|||||||||:||||||||||||:||||||.||       |||||.||.:|||
  Rat   125 VTYMTREEAKVAIEKLSGHQFEDYSFKISYIPDEELSSPSPPHRA-------REQGHGPGSSSQA 182

Human   196 RQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   183 RQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEA 247

Human   261 CRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIY 325
            ||||||||||||||||||||:|||||||||.||||||||||||||||||||||||||||||||||
  Rat   248 CRMILEIMQKEADETKLAEEVPLKILAHNGFVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIY 312

Human   326 NPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPP 390
            |||||||||||:|||||||:||||||||||||||||||||||||||||||||||||||||||.||
  Rat   313 NPERTITVKGTIEACASAEMEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLPPP 377

Human   391 AGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH 455
            ||||||||:.|||||.|||||||||||||.||||||||||||||.|:||||||||||||||||||
  Rat   378 AGPRGAPPSPPYHPFATHSGYFSSLYPHHHFGPFPHHHSYPEQETVSLFIPTQAVGAIIGKKGAH 442

Human   456 IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHI 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   443 IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHI 507

Human   521 RVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIV 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   508 RVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIV 572

Human   586 QQVKQQEQKYPQGVASQRSK 605
            ||||||.||||||||.||||
  Rat   573 QQVKQQAQKYPQGVAPQRSK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070	75/75 (100%)
		RRM2_IGF2BP2	82..163	CDD:410038	69/80 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..194		18/30 (60%)
		KH-I_IGF2BP2_rpt1	201..274	CDD:411919	72/72 (100%)
		KH-I_IGF2BP2_rpt2	282..358	CDD:411922	72/75 (96%)
		KH-I_IGF2BP2_rpt3	432..508	CDD:411925	73/75 (97%)
		KH-I_IGF2BP2_rpt4	515..592	CDD:411928	76/76 (100%)
Igf2bp2	NP_001257527.1	RRM1_IGF2BP2	2..78	CDD:241070	75/75 (100%)
		RRM2_IGF2BP2	82..157	CDD:410038	69/80 (86%)
		KH-I_IGF2BP2_rpt1	188..261	CDD:411919	72/72 (100%)
		KH-I	265..360	CDD:469614	90/94 (96%)
		KH-I_IGF2BP2_rpt3	419..495	CDD:411925	73/75 (97%)
		KH-I_IGF2BP2_rpt4	502..578	CDD:411928	75/75 (100%)