Protein Alignment IGF2BP2 and igf2bp2a

DIOPT Version :10

• Sequence 1: NP_001278798.1
• Gene: IGF2BP2 / 10644
• HGNCID: 28867
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_001108030.2
• Gene: igf2bp2a / 100136839
• ZFINID: ZDB-GENE-070912-44
• Length: 607
• Species: Danio rerio
• Alignment Length: 613
• Identity: 470/613 - (76%)
• Similarity: 525/613 - (85%)
• Gaps: 15/613 - (2%)

Human     2 MNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHG 66
            |||||:|||||:||.:||:||||:||||:..||||||||||||:|||||||:|||||||||||||
Zfish     1 MNKLYVGNLSPSVTVEDLKQLFGERKLPVTDQVLLKSGYAFVDFPDQNWAIKAIETLSGKVELHG 65

Human    67 KIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVFAFSLVNTDTETAVVNV 131
            |::||||||.|||||||||||||||||||||||.|||||||||||||      ||||||||||||
Zfish    66 KVIEVDYSVPKKLRSRKIQIRNIPPHLQWEVLDSLLAQYGTVENVEQ------VNTDTETAVVNV 124

Human   132 TYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGT---- 192
            ||:|:||||:|:|||....||:||||:|||.|.:.::..|..|.:||..:||||...||.:
Zfish   125 TYSTKEEAKVAVEKLIEQTFEDYSFKVSYIMDMDAAAALPGTRNRRGGRTSREQDSQPGTSGSSL 189

Human   193 -SQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEG 256
             |:.:|.|||||:|||||||||||||||||||||||||||:||||||||:||||||:|||:||||
Zfish   190 GSRQKQPDFPLRMLVPTQFVGAIIGKEGLTIKNITKQTQSKVDIHRKENAGAAEKPITIHSTPEG 254

Human   257 TSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQD 321
            .|.||.||::||||||.:||:.|:|||||||||.|||||||||||||||||.:|.||||||||||
Zfish   255 CSTACHMIMDIMQKEAVDTKVTEDIPLKILAHNSLVGRLIGKEGRNLKKIEEDTETKITISSLQD 319

Human   322 LSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSV 386
            |:||||||||.|||::|||..||:|||||||||:|||:.|:|||:||||||:|||||||||||||
Zfish   320 LTIYNPERTIIVKGSIEACCRAEVEIMKKLREAYENDVAAINQQSNLIPGLSLSALGIFSTGLSV 384

Human   387 LSPPAGPRGAPPAAP--YHPFTTHSGYFSSLYPHHQFGPFPHHHSY-PEQEIVNLFIPTQAVGAI 448
            |.|.|||||.||..|  |:||..||.....||.........|.|:. ||||:|.|||||||||||
Zfish   385 LPPAAGPRGIPPVPPTGYNPFLGHSSQLGGLYGVPPASGISHQHTQAPEQEVVYLFIPTQAVGAI 449

Human   449 IGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEE 513
            |||||.|||||||||||||||||||.|||::|||||||||||||||||||||||||||||..|||
Zfish   450 IGKKGQHIKQLARFAGASIKIAPAESPDVTQRMVIITGPPEAQFKAQGRIFGKLKEENFFTAKEE 514

Human   514 VKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQ 578
            ||||.||:||||.||||||||||||||||||||||||||||||||||:||.|:|.||||||||||
Zfish   515 VKLETHIKVPSSAAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENDEVFVKISGHFFASQTAQ 579

Human   579 RKIREIVQQVKQQEQKYPQGV-ASQRSK 605
            ||||||:|||||||||:.||. .:.|||
Zfish   580 RKIREIIQQVKQQEQKHQQGAPTTPRSK 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070	61/75 (81%)
		RRM2_IGF2BP2	82..163	CDD:410038	63/80 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..194		11/35 (31%)
		KH-I_IGF2BP2_rpt1	201..274	CDD:411919	62/72 (86%)
		KH-I_IGF2BP2_rpt2	282..358	CDD:411922	63/75 (84%)
		KH-I_IGF2BP2_rpt3	432..508	CDD:411925	69/75 (92%)
		KH-I_IGF2BP2_rpt4	515..592	CDD:411928	68/76 (89%)
igf2bp2a	NP_001108030.2	RRM1_IGF2BP2	1..77	CDD:241070	61/75 (81%)
		RRM_SF	81..156	CDD:473069	63/80 (79%)
		KH-I_IGF2BP2_rpt1	199..272	CDD:411919	62/72 (86%)
		KH-I	277..371	CDD:469614	76/93 (82%)
		KH-I_IGF2BP2_rpt3	433..509	CDD:411925	69/75 (92%)
		KH-I_IGF2BP2_rpt4	516..593	CDD:411928	68/76 (89%)