Protein Alignment IGF2BP3 and igf2bp3

DIOPT Version :10

• Sequence 1: XP_047275738.1
• Gene: IGF2BP3 / 10643
• HGNCID: 28868
• Length: 634
• Species: Homo sapiens
• Sequence 2: NP_001017139.1
• Gene: igf2bp3 / 549893
• XenbaseID: XB-GENE-483018
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 536
• Identity: 446/536 - (83%)
• Similarity: 481/536 - (89%)
• Gaps: 15/536 - (2%)

Human   114 GKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVN 178
            ||:|||||.||||||||||||.|||||||||||||||||||||.|||.||:||||||||||||||
 Frog    59 GKVELHGKVIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTDSETAVVN 123

Human   179 VTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQ---------PRGRRGLGQRGS 234
            |||::|:.|||.|:||||:||||::|||.|||||||.||.|.||         |:||||.||||.
 Frog   124 VTYANKEHARQGLEKLNGYQLENYSLKVTYIPDEMATQQAPSQQLQQQPQQQHPQGRRGFGQRGP 188

Human   235 SRQGSPGSVSKQKP-CDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKS 298
            :||||||:.::.|| .::|||:||||||||||||||||||||||||||||||:|||||||||||.
 Frog   189 ARQGSPGAAARPKPQSEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKP 253

Human   299 ITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDT 363
            |||.|||||.|||||.|:|||.|||||.|||||||||||||||||||||||||||||||||||||
 Frog   254 ITIHSTPEGCSAACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDT 318

Human   364 KITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNAL 428
            ||||||||:||||||||||||||::|.|||||||||||||||||||||:||||||||||||||||
 Frog   319 KITISPLQDLTLYNPERTITVKGSIEACAKAEEEIMKKIRESYENDIAAMNLQAHLIPGLNLNAL 383

Human   429 GLFPP-TSGMPPPTSGPPSAMT-PPYPQF-EQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFA 490
            ||||| :||||||:.|.||..| ..||.| :|.|:||||||||||:|||||||||||||||||||
 Frog   384 GLFPPSSSGMPPPSVGVPSPTTSTSYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFA 448

Human   491 GASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAG 555
            ||||||||||.||||:||||||||||||||||||||||:|||||..|||||||||||:|||:|||
 Frog   449 GASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLEAHIKVPSYAAG 513

Human   556 RVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVK--QH 618
            ||||||||||||||||:||||||||||||||||||||||||||||.|:|||||||||.||:  |.
 Frog   514 RVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEILAQVRRQQQ 578

Human   619 QQQKALQSGPPQSRRK 634
            ||||..|||.||.|||
 Frog   579 QQQKTAQSGQPQPRRK 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP3	XP_047275738.1	RRM_SF	<114..132	CDD:473069	15/17 (88%)
		RRM2_IGF2BP3	136..211	CDD:410039	61/74 (82%)
		KH-I_IGF2BP3_rpt1	252..327	CDD:411920	66/74 (89%)
		KH-I	330..424	CDD:469614	88/93 (95%)
		KH-I_IGF2BP3_rpt3	457..534	CDD:411926	70/76 (92%)
		KH-I_IGF2BP1_rpt4	542..617	CDD:411927	68/76 (89%)
igf2bp3	NP_001017139.1	RRM1_IGF2BP3	1..77	CDD:410036	15/17 (88%)
		RRM2_IGF2BP3	81..156	CDD:410039	61/74 (82%)
		KH-I_IGF2BP1_rpt1	207..282	CDD:411918	66/74 (89%)
		KH-I	285..379	CDD:469614	88/93 (95%)
		KH-I	415..492	CDD:469614	70/76 (92%)
		KH-I	500..571	CDD:469614	65/70 (93%)