Protein Alignment IGF2BP3 and Imp

DIOPT Version :10

• Sequence 1: XP_047275738.1
• Gene: IGF2BP3 / 10643
• HGNCID: 28868
• Length: 634
• Species: Homo sapiens
• Sequence 2: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 214/550 - (38%)
• Similarity: 315/550 - (57%)
• Gaps: 80/550 - (14%)

Human   137 KLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNT-DSETAVVNVTYSSKDQARQALDKLNGFQLE 200
            |:.|..||...::|.::.||..||:|:.||.::: |..|..|::|:.:.:||::|...|||.:.|
  Fly    43 KILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPEQAQRAAVGLNGVEFE 107

Human   201 NFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAI 265
            .         .::.|:|....|.|.:|      :.|...||.....:..|.|||:||.::.||||
  Fly   108 G---------SKLHAEQLDKNQRRSQR------NQRNPYPGMPGPGRQADFPLRILVQSEMVGAI 157

Human   266 IGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTE 330
            ||::|:|||.||:|:::::|||||||.|:.||||||...||..:.|||.|||:|.:||......|
  Fly   158 IGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRILEVMQQEAISTNKGE 222

Human   331 ------EIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVE 389
                  ||.||||||||.:||:|||.|..:|:|.||||||||:|.:.::..:|.||.|||||.:|
  Fly   223 LSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDINSFNLERIITVKGLIE 287

Human   390 TCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGP---------- 444
            ..::||.:|..|:|:|||||:.:|..|:.:.|||:..|: :..|.:||...||.|
  Fly   288 NMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAM-MSTPGNGMVFNTSMPFPSCQSFAMS 351

Human   445 --PSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAP---DA 504
              |:::.||.  |.....||.:|:||..:||||||.:|.||:.:.||:.||:||||.:|.   |.
  Fly   352 KTPASVVPPV--FPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQ 414

Human   505 KV-RMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNEL 568
            :. |.|.|.|.||.|:|||..|:.|::||.|:...::|:|...:.|.|...||:|||||:.|.||
  Fly   415 QTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVREL 479

Human   569 QNLSSAEVVVPR----------DQTPDENDQVVVKITGHFYACQVAQRKIQEIL----------- 612
            |.::.:.:.:|.          ::||       |.|.|.||:.|.|||:|:.::
  Fly   480 QRVTGSVIKLPEHALAPPSGGDEETP-------VHIIGLFYSVQSAQRRIRAMMLSTNPPPITKK 537

Human   613 -----TQVKQHQQQKA------LQSGPPQS 631
                 .|::|.||..|      .|...|||
  Fly   538 QKAAKEQLQQQQQSLAGAASSGSQQQQPQS 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP3	XP_047275738.1	RRM_SF	<114..132	CDD:473069
		RRM2_IGF2BP3	136..211	CDD:410039	23/74 (31%)
		KH-I_IGF2BP3_rpt1	252..327	CDD:411920	43/74 (58%)
		KH-I	330..424	CDD:469614	51/99 (52%)
		KH-I_IGF2BP3_rpt3	457..534	CDD:411926	38/80 (48%)
		KH-I_IGF2BP1_rpt4	542..617	CDD:411927	28/100 (28%)
Imp	NP_001245616.1	RRM2_VICKZ	42..118	CDD:409794	25/83 (30%)
		KH-I_IGF2BP_rpt1	144..211	CDD:411828	40/66 (61%)
		KH-I_IGF2BP_rpt2	231..302	CDD:411829	38/70 (54%)
		KH-I_IGF2BP_rpt3	368..437	CDD:411830	34/68 (50%)
		KH-I_IGF2BP_rpt4	455..523	CDD:411831	25/74 (34%)