Protein Alignment IGF2BP3 and igf2bp3

DIOPT Version :10

• Sequence 1: XP_047275738.1
• Gene: IGF2BP3 / 10643
• HGNCID: 28868
• Length: 634
• Species: Homo sapiens
• Sequence 2: XP_009292473.1
• Gene: igf2bp3 / 30967
• ZFINID: ZDB-GENE-000308-1
• Length: 607
• Species: Danio rerio
• Alignment Length: 551
• Identity: 410/551 - (74%)
• Similarity: 453/551 - (82%)
• Gaps: 32/551 - (5%)

Human   114 GKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVN 178
            ||:|||||.:|||||||||||..||||||||||:||||||.||.|||.||||||||||:||||||
Zfish    59 GKVELHGKVLEVEHSVPKRQRSCKLQIRNIPPHMQWEVLDGLLAQYGTVESCEQVNTDTETAVVN 123

Human   179 VTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSV 243
            |.|.:|||||:|:||||||.:||:.|||:|||||.||...|  ...||||...||..|||||...
Zfish   124 VRYGAKDQAREAMDKLNGFLMENYALKVSYIPDETAAADAP--AVGGRRGFNPRGPPRQGSPSLG 186

Human   244 SKQK-PCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEG 307
            ::.| ..|:|||||||||||||||||||||||||||||.||||:|||||||||||.||:.|||||
Zfish   187 ARPKLQSDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRKENAGAAEKPITVHSTPEG 251

Human   308 TSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQE 372
            .|:||::|:|||.|||.|.|.|||||||||||||||||||||||||||||||||||||||||||:
Zfish   252 CSSACRNIMEIMQKEAIDTKITEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQD 316

Human   373 LTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFP-PTSG 436
            ||||||||||||||.::.|||||||||||:|||||||:|:|:||::|||||||||||||| ..||
Zfish   317 LTLYNPERTITVKGTLDACAKAEEEIMKKVRESYENDVAAMHLQSNLIPGLNLNALGLFPGAASG 381

Human   437 --MPPPTSGPPSAMTPPYPQF--------------------------EQSETETVHLFIPALSVG 473
              .|...||||......|..|                          .|.|:||||||||||:||
Zfish   382 GISPSVVSGPPPGAQAGYQSFGCSGFEGEVPFWASTLSSNSGCTAFSAQMESETVHLFIPALAVG 446

Human   474 AIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPK 538
            ||||||||||||||||||||||||||:..|||.|||||:|||||||||||||:||:|||||..||
Zfish   447 AIIGKQGQHIKQLSRFAGASIKIAPADGIDAKQRMVIISGPPEAQFKAQGRIFGKLKEENFFGPK 511

Human   539 EEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQV 603
            |||||||||:|||||||||||||||||||||||:||||||||||||||||||||||||||||.|:
Zfish   512 EEVKLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQL 576

Human   604 AQRKIQEILTQVKQHQQQKALQSGPPQSRRK 634
            ||||||||::||::.||.|...:|||.:|||
Zfish   577 AQRKIQEIISQVRRQQQPKPSAAGPPVARRK 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP3	XP_047275738.1	RRM_SF	<114..132	CDD:473069	14/17 (82%)
		RRM2_IGF2BP3	136..211	CDD:410039	58/74 (78%)
		KH-I_IGF2BP3_rpt1	252..327	CDD:411920	62/74 (84%)
		KH-I	330..424	CDD:469614	82/93 (88%)
		KH-I_IGF2BP3_rpt3	457..534	CDD:411926	66/76 (87%)
		KH-I_IGF2BP1_rpt4	542..617	CDD:411927	68/74 (92%)
igf2bp3	XP_009292473.1	RRM_SF	1..77	CDD:473069	14/17 (82%)
		RRM2_IGF2BP3	81..156	CDD:410039	58/74 (78%)
		KH-I	196..271	CDD:469614	62/74 (84%)
		KH-I	274..368	CDD:469614	82/93 (88%)
		KH-I_IGF2BP3_rpt3	430..507	CDD:411926	66/76 (87%)
		KH-I_IGF2BP1_rpt4	515..590	CDD:411927	68/74 (92%)